Novel method for synthesizing 2-fluoro-3-chloro-5-trifluoromethylpyridine

The invention relates to a novel method for synthesizing 2-fluoro-3-chloro-5-trifluoromethylpyridine. The method comprises the following steps of: (1) taking methylbenzene as a dehydrant, heating a mixture of solvent, potassium fluoride and phase transfer catalyst up to the temperature of between 80...

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Bibliographische Detailangaben
Hauptverfasser:	YANG SHOUHAI, WANG SHUGANG, ZHOU DIANHAI, RUI ZHONGNAN, KONG XINFU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention relates to a novel method for synthesizing 2-fluoro-3-chloro-5-trifluoromethylpyridine. The method comprises the following steps of: (1) taking methylbenzene as a dehydrant, heating a mixture of solvent, potassium fluoride and phase transfer catalyst up to the temperature of between 80 and 135 DEG C and refluxing for 3 hours, and removing water in the solvent and the potassium fluoride by taking the methylbenzene as the dehydrant; and (2) adding 2,3-dichloro-5-trifluoromethylpyridine in the mixture for reaction for 5 hours at a temperature of between 105 and 135 DEG C, and afterthe reaction, post-treating the reaction product to obtain the 2-fluoro-3-chloro-5-trifluoromethylpyridine in high purity. The yield of the method is 94.7 percent, and the purity of the 2-fluoro-3-chloro-5-trifluoromethylpyridine synthesized by the method is 98.5 percent.