Preparation method of thymopeptide-5
The invention discloses a preparation method of thymopeptide-5, comprising the following steps: using tyrosine benzyl ester hydrochloride as a starting material; using N-methyl morpholine as a catalyst; adopting alkyl chloroformate as an activating agent and activating protected amino acid to form h...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention discloses a preparation method of thymopeptide-5, comprising the following steps: using tyrosine benzyl ester hydrochloride as a starting material; using N-methyl morpholine as a catalyst; adopting alkyl chloroformate as an activating agent and activating protected amino acid to form high-activity mixed anhydride which reacts with exposed amino acid or peptide of an amino end. The high-purity thymopeptide-5 is prepared by the steps: dipeptide combination, kyrine combination, tetrapeptide combination, pentapeptide combination, crude generation and purification. The method simplifies a technology, has little three-waste pollution and is convenient to implement industrially. |
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