Process for the preparation of ccr-2 antagonist

Process for the preparation of ccr-2 antagonist

The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: JAVADI GARY, LI WENJIE, GE MIN, JENSEN MARK, LARSEN ROBERT, YANG LIHU, HOERRNER SCOTT, SZUMIGALA ELIZABETH, CAI DONGWEI, FLEITZ FRED, NELSON DORIAN, ZHOU CHANGYOU
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator JAVADI GARY
LI WENJIE
GE MIN
JENSEN MARK
LARSEN ROBERT
YANG LIHU
HOERRNER SCOTT
SZUMIGALA ELIZABETH
CAI DONGWEI
FLEITZ FRED
NELSON DORIAN
ZHOU CHANGYOU
description The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN101160286A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN101160286A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN101160286A3</originalsourceid><addsrcrecordid>eNrjZNAPKMpPTi0uVkjLL1IoyUhVKChKLUgsSizJzM9TyE9TSE4u0jVSSMwrSUzPz8ssLuFhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGhoZmBkYWZo7GxKgBAAFIKng</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Process for the preparation of ccr-2 antagonist</title><source>esp@cenet</source><creator>JAVADI GARY ; LI WENJIE ; GE MIN ; JENSEN MARK ; LARSEN ROBERT ; YANG LIHU ; HOERRNER SCOTT ; SZUMIGALA ELIZABETH ; CAI DONGWEI ; FLEITZ FRED ; NELSON DORIAN ; ZHOU CHANGYOU</creator><creatorcontrib>JAVADI GARY ; LI WENJIE ; GE MIN ; JENSEN MARK ; LARSEN ROBERT ; YANG LIHU ; HOERRNER SCOTT ; SZUMIGALA ELIZABETH ; CAI DONGWEI ; FLEITZ FRED ; NELSON DORIAN ; ZHOU CHANGYOU</creatorcontrib><description>The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080409&amp;DB=EPODOC&amp;CC=CN&amp;NR=101160286A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080409&amp;DB=EPODOC&amp;CC=CN&amp;NR=101160286A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JAVADI GARY</creatorcontrib><creatorcontrib>LI WENJIE</creatorcontrib><creatorcontrib>GE MIN</creatorcontrib><creatorcontrib>JENSEN MARK</creatorcontrib><creatorcontrib>LARSEN ROBERT</creatorcontrib><creatorcontrib>YANG LIHU</creatorcontrib><creatorcontrib>HOERRNER SCOTT</creatorcontrib><creatorcontrib>SZUMIGALA ELIZABETH</creatorcontrib><creatorcontrib>CAI DONGWEI</creatorcontrib><creatorcontrib>FLEITZ FRED</creatorcontrib><creatorcontrib>NELSON DORIAN</creatorcontrib><creatorcontrib>ZHOU CHANGYOU</creatorcontrib><title>Process for the preparation of ccr-2 antagonist</title><description>The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAPKMpPTi0uVkjLL1IoyUhVKChKLUgsSizJzM9TyE9TSE4u0jVSSMwrSUzPz8ssLuFhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGhoZmBkYWZo7GxKgBAAFIKng</recordid><startdate>20080409</startdate><enddate>20080409</enddate><creator>JAVADI GARY</creator><creator>LI WENJIE</creator><creator>GE MIN</creator><creator>JENSEN MARK</creator><creator>LARSEN ROBERT</creator><creator>YANG LIHU</creator><creator>HOERRNER SCOTT</creator><creator>SZUMIGALA ELIZABETH</creator><creator>CAI DONGWEI</creator><creator>FLEITZ FRED</creator><creator>NELSON DORIAN</creator><creator>ZHOU CHANGYOU</creator><scope>EVB</scope></search><sort><creationdate>20080409</creationdate><title>Process for the preparation of ccr-2 antagonist</title><author>JAVADI GARY ; LI WENJIE ; GE MIN ; JENSEN MARK ; LARSEN ROBERT ; YANG LIHU ; HOERRNER SCOTT ; SZUMIGALA ELIZABETH ; CAI DONGWEI ; FLEITZ FRED ; NELSON DORIAN ; ZHOU CHANGYOU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN101160286A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2008</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>JAVADI GARY</creatorcontrib><creatorcontrib>LI WENJIE</creatorcontrib><creatorcontrib>GE MIN</creatorcontrib><creatorcontrib>JENSEN MARK</creatorcontrib><creatorcontrib>LARSEN ROBERT</creatorcontrib><creatorcontrib>YANG LIHU</creatorcontrib><creatorcontrib>HOERRNER SCOTT</creatorcontrib><creatorcontrib>SZUMIGALA ELIZABETH</creatorcontrib><creatorcontrib>CAI DONGWEI</creatorcontrib><creatorcontrib>FLEITZ FRED</creatorcontrib><creatorcontrib>NELSON DORIAN</creatorcontrib><creatorcontrib>ZHOU CHANGYOU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JAVADI GARY</au><au>LI WENJIE</au><au>GE MIN</au><au>JENSEN MARK</au><au>LARSEN ROBERT</au><au>YANG LIHU</au><au>HOERRNER SCOTT</au><au>SZUMIGALA ELIZABETH</au><au>CAI DONGWEI</au><au>FLEITZ FRED</au><au>NELSON DORIAN</au><au>ZHOU CHANGYOU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for the preparation of ccr-2 antagonist</title><date>2008-04-09</date><risdate>2008</risdate><abstract>The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN101160286A
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Process for the preparation of ccr-2 antagonist
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A28%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JAVADI%20GARY&rft.date=2008-04-09&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN101160286A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true