Conjugates with anti-inflammatory activity

The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: -X 1 -(CH 2 ) m -Q-(CH 2 ) n -X 2 -IX -X 1 -(CH 2 ) m -V-(CH...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	POLJAK VISNJA, SIJAN GORDANA, SELMANI SELVIRA, MARKOVIC STRIBOR, TOMASKOVIC LINDA, MERCEP MLADEN, MESIC MILAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: -X 1 -(CH 2 ) m -Q-(CH 2 ) n -X 2 -IX -X 1 -(CH 2 ) m -V-(CH 2 ) p -Q-(CH 2 ) n -X 1 -XIII Z represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.