2,4 (4,6) pyrimidine derivatives
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alk...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ROMBOUTS FREDERIK J. R FREYNE EDDY JEAN E EMBRECHTS WERNER C. J WILLEMS MARC VAN EMELEN KRISTOF VAN BRANDT SVEN F. A |
| description | The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alkyl-, -C1-6alkyl-CO-NH-, -C1-6alkyl-NH-CO-, -C1-2alkyl-CO-Het -CO-, -C1-3alkyl-NH-CO-Het -, -Het -C1-3alkyl-CO-NH-C1-3alkyl-, -C1-2alkyl-NH-CO-L -NH-, -NH-CO-L -NH-, -C1-2alkyl-CO-NH-L -CO-, -C1-2alkyl-NH-CO-L -NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L -CO-NH-C1-3alkyl-, -C1-2alkyl-NR -CH2-CO-NH-C1-3alkyl-, Het -CO-C1-2alkyl-, -C1-5alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR -CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Het -CO-, or -C1-3alkyl-CO-Het -CO-NH-; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; R and R each independently represent h |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN101072779BB</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN101072779BB</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN101072779BB3</originalsourceid><addsrcrecordid>eNrjZFAw0jFR0DDRMdNUKKgsyszNTMnMS1VISS3KLEssySxLLeZhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGhgbmRubmlk5OxkQpAgDl5CRM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2,4 (4,6) pyrimidine derivatives</title><source>esp@cenet</source><creator>ROMBOUTS FREDERIK J. R ; FREYNE EDDY JEAN E ; EMBRECHTS WERNER C. J ; WILLEMS MARC ; VAN EMELEN KRISTOF ; VAN BRANDT SVEN F. A</creator><creatorcontrib>ROMBOUTS FREDERIK J. R ; FREYNE EDDY JEAN E ; EMBRECHTS WERNER C. J ; WILLEMS MARC ; VAN EMELEN KRISTOF ; VAN BRANDT SVEN F. A</creatorcontrib><description>The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alkyl-, -C1-6alkyl-CO-NH-, -C1-6alkyl-NH-CO-, -C1-2alkyl-CO-Het -CO-, -C1-3alkyl-NH-CO-Het -, -Het -C1-3alkyl-CO-NH-C1-3alkyl-, -C1-2alkyl-NH-CO-L -NH-, -NH-CO-L -NH-, -C1-2alkyl-CO-NH-L -CO-, -C1-2alkyl-NH-CO-L -NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L -CO-NH-C1-3alkyl-, -C1-2alkyl-NR -CH2-CO-NH-C1-3alkyl-, Het -CO-C1-2alkyl-, -C1-5alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR -CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Het -CO-, or -C1-3alkyl-CO-Het -CO-NH-; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; R and R each independently represent h</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101222&DB=EPODOC&CC=CN&NR=101072779B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101222&DB=EPODOC&CC=CN&NR=101072779B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ROMBOUTS FREDERIK J. R</creatorcontrib><creatorcontrib>FREYNE EDDY JEAN E</creatorcontrib><creatorcontrib>EMBRECHTS WERNER C. J</creatorcontrib><creatorcontrib>WILLEMS MARC</creatorcontrib><creatorcontrib>VAN EMELEN KRISTOF</creatorcontrib><creatorcontrib>VAN BRANDT SVEN F. A</creatorcontrib><title>2,4 (4,6) pyrimidine derivatives</title><description>The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alkyl-, -C1-6alkyl-CO-NH-, -C1-6alkyl-NH-CO-, -C1-2alkyl-CO-Het -CO-, -C1-3alkyl-NH-CO-Het -, -Het -C1-3alkyl-CO-NH-C1-3alkyl-, -C1-2alkyl-NH-CO-L -NH-, -NH-CO-L -NH-, -C1-2alkyl-CO-NH-L -CO-, -C1-2alkyl-NH-CO-L -NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L -CO-NH-C1-3alkyl-, -C1-2alkyl-NR -CH2-CO-NH-C1-3alkyl-, Het -CO-C1-2alkyl-, -C1-5alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR -CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Het -CO-, or -C1-3alkyl-CO-Het -CO-NH-; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; R and R each independently represent h</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAw0jFR0DDRMdNUKKgsyszNTMnMS1VISS3KLEssySxLLeZhYE1LzClO5YXS3AxKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGhgbmRubmlk5OxkQpAgDl5CRM</recordid><startdate>20101222</startdate><enddate>20101222</enddate><creator>ROMBOUTS FREDERIK J. R</creator><creator>FREYNE EDDY JEAN E</creator><creator>EMBRECHTS WERNER C. J</creator><creator>WILLEMS MARC</creator><creator>VAN EMELEN KRISTOF</creator><creator>VAN BRANDT SVEN F. A</creator><scope>EVB</scope></search><sort><creationdate>20101222</creationdate><title>2,4 (4,6) pyrimidine derivatives</title><author>ROMBOUTS FREDERIK J. R ; FREYNE EDDY JEAN E ; EMBRECHTS WERNER C. J ; WILLEMS MARC ; VAN EMELEN KRISTOF ; VAN BRANDT SVEN F. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN101072779BB3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ROMBOUTS FREDERIK J. R</creatorcontrib><creatorcontrib>FREYNE EDDY JEAN E</creatorcontrib><creatorcontrib>EMBRECHTS WERNER C. J</creatorcontrib><creatorcontrib>WILLEMS MARC</creatorcontrib><creatorcontrib>VAN EMELEN KRISTOF</creatorcontrib><creatorcontrib>VAN BRANDT SVEN F. A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ROMBOUTS FREDERIK J. R</au><au>FREYNE EDDY JEAN E</au><au>EMBRECHTS WERNER C. J</au><au>WILLEMS MARC</au><au>VAN EMELEN KRISTOF</au><au>VAN BRANDT SVEN F. A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2,4 (4,6) pyrimidine derivatives</title><date>2010-12-22</date><risdate>2010</risdate><abstract>The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH; Y represents -C3-9alkyl-, -C3-9alkenyl-, -C1-5alkyl-NR -C1-5alkyl-, -C1-5alkyl-NR -CO-C1 -5alkyl-, -C1-6alkyl-CO-NH-, -C1-6alkyl-NH-CO-, -C1-2alkyl-CO-Het -CO-, -C1-3alkyl-NH-CO-Het -, -Het -C1-3alkyl-CO-NH-C1-3alkyl-, -C1-2alkyl-NH-CO-L -NH-, -NH-CO-L -NH-, -C1-2alkyl-CO-NH-L -CO-, -C1-2alkyl-NH-CO-L -NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L -CO-NH-C1-3alkyl-, -C1-2alkyl-NR -CH2-CO-NH-C1-3alkyl-, Het -CO-C1-2alkyl-, -C1-5alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR -CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Het -CO-, or -C1-3alkyl-CO-Het -CO-NH-; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; X represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR -C1-2alkyl-, -CO-NR -, Het -C1-2alkyl- or C1-2alkyl; R and R each independently represent h</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN101072779BB |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2,4 (4,6) pyrimidine derivatives |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T05%3A14%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ROMBOUTS%20FREDERIK%20J.%20R&rft.date=2010-12-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN101072779BB%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |