Substituted triazines as prion protein ligands and their use to detect or remove prions

The invention relates to use for formula (I) compound: in which, R is identical or different from R , each is optionally the substituted alkyl, the substituted cycloalkyl, the substituted aryl or the substituted heteroary; R is hydrogen or aryl substituent or R , which is optionally the solid carrie...

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1. Verfasser:	PEARSON JAMES CHRISTOPHER,TATTON HELEN ROSEMARY,GURGEL PATRICK VASCONCELOS
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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creator	PEARSON JAMES CHRISTOPHER,TATTON HELEN ROSEMARY,GURGEL PATRICK VASCONCELOS
description	The invention relates to use for formula (I) compound: in which, R is identical or different from R , each is optionally the substituted alkyl, the substituted cycloalkyl, the substituted aryl or the substituted heteroary; R is hydrogen or aryl substituent or R , which is optionally the solid carrier connecting via interval base; Z represents oxygen atom, sulphur atom or NR ; Y represents oxygen atom, sulphur atom or NR ; in which, R and R may be identical or difference, represents hydrogen, optionally substituted alkyl containing 1 - 6 carbon atoms, the substituted phenyl, the substituted benzyl, or the substituted beta-phenethyl; one of X and X represents nitrogen atom, and the other of X and X represents nitrogen atom or CR , in which, R represents hydrogen, or aryl substituent; it may be used to be prion protein ligands.
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subjects	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
title	Substituted triazines as prion protein ligands and their use to detect or remove prions
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