N,N'-disubstituted piperazine derivative, and its preparation method and medicinal composition and uses
The invention relates to field of medical design, medical chemistry and pharmaceutics. The invention intends to find out molecule that can activate or prevent potassium ion channel activity by employing computer on the basis of crystal three-dimensional structure of potassium ion channel, then deriv...
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| creator | JIANG HUALIANG ZHU WEILIANG GAO ZHAOBING TAN XIAOJIAN SHEN JIANHUA CHEN KAIXIAN ZHOU YU LUO XIAOMIN YU KUNQIAN HU GUOYUAN LIU HONG LI YANG ZHENG SUXIN YAO ZHIYI |
| description | The invention relates to field of medical design, medical chemistry and pharmaceutics. The invention intends to find out molecule that can activate or prevent potassium ion channel activity by employing computer on the basis of crystal three-dimensional structure of potassium ion channel, then derivatives sifted compound and provides N, N'- disubstituted piperazine derivatives and its salt accepted by pharmacy. The construction formula of said derivatives is expressed in following graph. The invention also relates to the method for preparing said derivatives and its salt and their application. Said compound can be used as activating agent or preventing agent for potassium ion channel, and the potassium ion can be selectively shifted in or out cell by activating or preventing the activity of potassium ion channel. The compound mentioned in this invention can be used to treat and/ or prevent cranial vascular disease relevant to physiological pathological and pharmacologia of cardiovascular system effectively. |
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The invention intends to find out molecule that can activate or prevent potassium ion channel activity by employing computer on the basis of crystal three-dimensional structure of potassium ion channel, then derivatives sifted compound and provides N, N'- disubstituted piperazine derivatives and its salt accepted by pharmacy. The construction formula of said derivatives is expressed in following graph. The invention also relates to the method for preparing said derivatives and its salt and their application. Said compound can be used as activating agent or preventing agent for potassium ion channel, and the potassium ion can be selectively shifted in or out cell by activating or preventing the activity of potassium ion channel. The compound mentioned in this invention can be used to treat and/ or prevent cranial vascular disease relevant to physiological pathological and pharmacologia of cardiovascular system effectively.</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100901&DB=EPODOC&CC=CN&NR=101007794B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100901&DB=EPODOC&CC=CN&NR=101007794B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JIANG HUALIANG</creatorcontrib><creatorcontrib>ZHU WEILIANG</creatorcontrib><creatorcontrib>GAO ZHAOBING</creatorcontrib><creatorcontrib>TAN XIAOJIAN</creatorcontrib><creatorcontrib>SHEN JIANHUA</creatorcontrib><creatorcontrib>CHEN KAIXIAN</creatorcontrib><creatorcontrib>ZHOU YU</creatorcontrib><creatorcontrib>LUO XIAOMIN</creatorcontrib><creatorcontrib>YU KUNQIAN</creatorcontrib><creatorcontrib>HU GUOYUAN</creatorcontrib><creatorcontrib>LIU HONG</creatorcontrib><creatorcontrib>LI YANG</creatorcontrib><creatorcontrib>ZHENG SUXIN</creatorcontrib><creatorcontrib>YAO ZHIYI</creatorcontrib><title>N,N'-disubstituted piperazine derivative, and its preparation method and medicinal composition and uses</title><description>The invention relates to field of medical design, medical chemistry and pharmaceutics. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N,N'-disubstituted piperazine derivative, and its preparation method and medicinal composition and uses |
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