Compuestos de indol y métodos de uso

La invención se refiere a compuestos heterocíclicos, sales farmacéuticamente aceptables de los mismos y preparaciones farmacéuticas de los mismos. También se describen en el presente documento las composiciones y el uso de dichos compuestos en métodos de tratamiento de enfermedades y afecciones medi...

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Hauptverfasser: David BORCHERDING, Jinyu LIU, Matthieu BARRAGUE, Roy VAZ, Claude BARBERIS, Anatoly RUVINSKY, Yi LI, Timothy Alan GILLESPY, Markus METZ, Bradford HIRTH, Zhongli GAO, Junkai LIAO, Sukanthini THURAIRATNAM, Alexandre GROSS, Andrew GOOD, Mark MUNSON, Gregory HURLBUT
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creator David BORCHERDING
Jinyu LIU
Matthieu BARRAGUE
Roy VAZ
Claude BARBERIS
Anatoly RUVINSKY
Yi LI
Timothy Alan GILLESPY
Markus METZ
Bradford HIRTH
Zhongli GAO
Junkai LIAO
Sukanthini THURAIRATNAM
Alexandre GROSS
Andrew GOOD
Mark MUNSON
Gregory HURLBUT
description La invención se refiere a compuestos heterocíclicos, sales farmacéuticamente aceptables de los mismos y preparaciones farmacéuticas de los mismos. También se describen en el presente documento las composiciones y el uso de dichos compuestos en métodos de tratamiento de enfermedades y afecciones mediadas por una actividad deficiente de CFTR, en particular la fibrosis quística. The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Compuestos de indol y métodos de uso
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