Derivados espiráncos sustituidos de cadena lineal
La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el...
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| creator | LI, Kangying THURING, Johannes Wilhelmus John F DARVILLE, Nicolas Freddy J DAI, Xuedong XU, Yanping FANG, Lichao FU, Liqiang NG, Alicia Tee Fuay URBANIETZ, Gregor Thomas DENG, Xiangjun MATON, William, Marc ZHAO, Qiwu PANDE, Vineet LIU, Yingtao CAI, Wei QUEROLLE, Olivier Alexis Georges CLEATOR, Edward LIU, Lianzhu LI, Ming |
| description | La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes. |
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The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230203&DB=EPODOC&CC=CL&NR=2022001583A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230203&DB=EPODOC&CC=CL&NR=2022001583A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI, Kangying</creatorcontrib><creatorcontrib>THURING, Johannes Wilhelmus John F</creatorcontrib><creatorcontrib>DARVILLE, Nicolas Freddy J</creatorcontrib><creatorcontrib>DAI, Xuedong</creatorcontrib><creatorcontrib>XU, Yanping</creatorcontrib><creatorcontrib>FANG, Lichao</creatorcontrib><creatorcontrib>FU, Liqiang</creatorcontrib><creatorcontrib>NG, Alicia Tee Fuay</creatorcontrib><creatorcontrib>URBANIETZ, Gregor Thomas</creatorcontrib><creatorcontrib>DENG, Xiangjun</creatorcontrib><creatorcontrib>MATON, William, Marc</creatorcontrib><creatorcontrib>ZHAO, Qiwu</creatorcontrib><creatorcontrib>PANDE, Vineet</creatorcontrib><creatorcontrib>LIU, Yingtao</creatorcontrib><creatorcontrib>CAI, Wei</creatorcontrib><creatorcontrib>QUEROLLE, Olivier Alexis Georges</creatorcontrib><creatorcontrib>CLEATOR, Edward</creatorcontrib><creatorcontrib>LIU, Lianzhu</creatorcontrib><creatorcontrib>LI, Ming</creatorcontrib><title>Derivados espiráncos sustituidos de cadena lineal</title><description>La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBySS3KLEtMyS9WSC0uyCw6vDAvGcguLi0uySwpzQSJp6QqJCempOYlKuRk5qUm5vAwsKYl5hSn8kJpbgZlN9cQZw_d1IL8eKAhicmpeakl8c4-RgZGRgYGhqYWxo6GxsSpAgDuri2u</recordid><startdate>20230203</startdate><enddate>20230203</enddate><creator>LI, Kangying</creator><creator>THURING, Johannes Wilhelmus John F</creator><creator>DARVILLE, Nicolas Freddy J</creator><creator>DAI, Xuedong</creator><creator>XU, Yanping</creator><creator>FANG, Lichao</creator><creator>FU, Liqiang</creator><creator>NG, Alicia Tee Fuay</creator><creator>URBANIETZ, Gregor Thomas</creator><creator>DENG, Xiangjun</creator><creator>MATON, William, Marc</creator><creator>ZHAO, Qiwu</creator><creator>PANDE, Vineet</creator><creator>LIU, Yingtao</creator><creator>CAI, Wei</creator><creator>QUEROLLE, Olivier Alexis Georges</creator><creator>CLEATOR, Edward</creator><creator>LIU, Lianzhu</creator><creator>LI, Ming</creator><scope>EVB</scope></search><sort><creationdate>20230203</creationdate><title>Derivados espiráncos sustituidos de cadena lineal</title><author>LI, Kangying ; THURING, Johannes Wilhelmus John F ; DARVILLE, Nicolas Freddy J ; DAI, Xuedong ; XU, Yanping ; FANG, Lichao ; FU, Liqiang ; NG, Alicia Tee Fuay ; URBANIETZ, Gregor Thomas ; DENG, Xiangjun ; MATON, William, Marc ; ZHAO, Qiwu ; PANDE, Vineet ; LIU, Yingtao ; CAI, Wei ; QUEROLLE, Olivier Alexis Georges ; CLEATOR, Edward ; LIU, Lianzhu ; LI, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CL2022001583A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LI, Kangying</creatorcontrib><creatorcontrib>THURING, Johannes Wilhelmus John F</creatorcontrib><creatorcontrib>DARVILLE, Nicolas Freddy J</creatorcontrib><creatorcontrib>DAI, Xuedong</creatorcontrib><creatorcontrib>XU, Yanping</creatorcontrib><creatorcontrib>FANG, Lichao</creatorcontrib><creatorcontrib>FU, Liqiang</creatorcontrib><creatorcontrib>NG, Alicia Tee Fuay</creatorcontrib><creatorcontrib>URBANIETZ, Gregor Thomas</creatorcontrib><creatorcontrib>DENG, Xiangjun</creatorcontrib><creatorcontrib>MATON, William, Marc</creatorcontrib><creatorcontrib>ZHAO, Qiwu</creatorcontrib><creatorcontrib>PANDE, Vineet</creatorcontrib><creatorcontrib>LIU, Yingtao</creatorcontrib><creatorcontrib>CAI, Wei</creatorcontrib><creatorcontrib>QUEROLLE, Olivier Alexis Georges</creatorcontrib><creatorcontrib>CLEATOR, Edward</creatorcontrib><creatorcontrib>LIU, Lianzhu</creatorcontrib><creatorcontrib>LI, Ming</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI, Kangying</au><au>THURING, Johannes Wilhelmus John F</au><au>DARVILLE, Nicolas Freddy J</au><au>DAI, Xuedong</au><au>XU, Yanping</au><au>FANG, Lichao</au><au>FU, Liqiang</au><au>NG, Alicia Tee Fuay</au><au>URBANIETZ, Gregor Thomas</au><au>DENG, Xiangjun</au><au>MATON, William, Marc</au><au>ZHAO, Qiwu</au><au>PANDE, Vineet</au><au>LIU, Yingtao</au><au>CAI, Wei</au><au>QUEROLLE, Olivier Alexis Georges</au><au>CLEATOR, Edward</au><au>LIU, Lianzhu</au><au>LI, Ming</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Derivados espiráncos sustituidos de cadena lineal</title><date>2023-02-03</date><risdate>2023</risdate><abstract>La presente invención se refiere a agentes farmacéuticos útiles para la terapia y/o profilaxis en un mamífero, a una composición farmacéutica que comprende tales compuestos y a su uso como inhibidores de la interacción proteína/proteína de la menina/MLL, útiles para tratar enfermedades tales como el cáncer, que incluye, sin carácter limitante, leucemia, síndrome mielodisplásico (SMD) y neoplasias mieloproliferativas (NMP); y diabetes.
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Derivados espiráncos sustituidos de cadena lineal |
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