Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
Se describen los compuestos de la Fórmula (I): o una sal del mismo, en donde: R1, R2, R4, R5, y m son definidos en el presente documento. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol quinasa alfa (DGK ?) y diacilglicerol quinasa z...
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| creator | Chetan Padmakar DARNE Upender VELAPARTHI Richard E. OLSON Prasada Rao JALAGAM Bireshwar DASGUPTA Hasibur RAHAMAN Denise C. GRUNENFELDER Saumya ROY Jayakumar Sankara WARRIER |
| description | Se describen los compuestos de la Fórmula (I): o una sal del mismo, en donde: R1, R2, R4, R5, y m son definidos en el presente documento. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol quinasa alfa (DGK ?) y diacilglicerol quinasa zeta (DGK?), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.
Disclosed are compounds of Formula (I):or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. |
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Disclosed are compounds of Formula (I):or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221014&DB=EPODOC&CC=CL&NR=2022000485A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221014&DB=EPODOC&CC=CL&NR=2022000485A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Chetan Padmakar DARNE</creatorcontrib><creatorcontrib>Upender VELAPARTHI</creatorcontrib><creatorcontrib>Richard E. OLSON</creatorcontrib><creatorcontrib>Prasada Rao JALAGAM</creatorcontrib><creatorcontrib>Bireshwar DASGUPTA</creatorcontrib><creatorcontrib>Hasibur RAHAMAN</creatorcontrib><creatorcontrib>Denise C. GRUNENFELDER</creatorcontrib><creatorcontrib>Saumya ROY</creatorcontrib><creatorcontrib>Jayakumar Sankara WARRIER</creatorcontrib><title>Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t</title><description>Se describen los compuestos de la Fórmula (I): o una sal del mismo, en donde: R1, R2, R4, R5, y m son definidos en el presente documento. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol quinasa alfa (DGK ?) y diacilglicerol quinasa zeta (DGK?), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.
Disclosed are compounds of Formula (I):or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNiz0KAjEQRrexEPUOA9ZCXBW2laBYWGq9hGSEgSQTdibeySvY7sX8wQPYfK9475s2V8upVBRlgYBQaKDAn00UKHOmyCBVlLS-hcD4VIoo4DkxOK90d4EH_J79-Ig1OgGdN5Obi4KLH2fN8ni42NMKC_coxXnMqL09t6ZtjTHbbrdfb_6rXgFBPFI</recordid><startdate>20221014</startdate><enddate>20221014</enddate><creator>Chetan Padmakar DARNE</creator><creator>Upender VELAPARTHI</creator><creator>Richard E. OLSON</creator><creator>Prasada Rao JALAGAM</creator><creator>Bireshwar DASGUPTA</creator><creator>Hasibur RAHAMAN</creator><creator>Denise C. GRUNENFELDER</creator><creator>Saumya ROY</creator><creator>Jayakumar Sankara WARRIER</creator><scope>EVB</scope></search><sort><creationdate>20221014</creationdate><title>Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t</title><author>Chetan Padmakar DARNE ; Upender VELAPARTHI ; Richard E. OLSON ; Prasada Rao JALAGAM ; Bireshwar DASGUPTA ; Hasibur RAHAMAN ; Denise C. GRUNENFELDER ; Saumya ROY ; Jayakumar Sankara WARRIER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CL2022000485A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Chetan Padmakar DARNE</creatorcontrib><creatorcontrib>Upender VELAPARTHI</creatorcontrib><creatorcontrib>Richard E. OLSON</creatorcontrib><creatorcontrib>Prasada Rao JALAGAM</creatorcontrib><creatorcontrib>Bireshwar DASGUPTA</creatorcontrib><creatorcontrib>Hasibur RAHAMAN</creatorcontrib><creatorcontrib>Denise C. GRUNENFELDER</creatorcontrib><creatorcontrib>Saumya ROY</creatorcontrib><creatorcontrib>Jayakumar Sankara WARRIER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chetan Padmakar DARNE</au><au>Upender VELAPARTHI</au><au>Richard E. OLSON</au><au>Prasada Rao JALAGAM</au><au>Bireshwar DASGUPTA</au><au>Hasibur RAHAMAN</au><au>Denise C. GRUNENFELDER</au><au>Saumya ROY</au><au>Jayakumar Sankara WARRIER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t</title><date>2022-10-14</date><risdate>2022</risdate><abstract>Se describen los compuestos de la Fórmula (I): o una sal del mismo, en donde: R1, R2, R4, R5, y m son definidos en el presente documento. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol quinasa alfa (DGK ?) y diacilglicerol quinasa zeta (DGK?), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.
Disclosed are compounds of Formula (I):or a salt thereof, wherein: R1, R2, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
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