Inhibidores de la arginasa

En el presente documento se describen compuestos que son inhibidores de al menos uno de ARG1 y ARG2 y composiciones que contienen los compuestos y métodos para sintetizar los compuestos. En el presente documento también se describe el uso de tales compuestos y composiciones para el tratamiento de un...

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Hauptverfasser: GRANGE, Rebecca Louise, GUNEY, Tezcan, KALISIAK, Jaroslaw, NEWCOMB, Eric Thomas, FOLEY, Corinne Nicole, TRAN, Anh Thu
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creator GRANGE, Rebecca Louise
GUNEY, Tezcan
KALISIAK, Jaroslaw
NEWCOMB, Eric Thomas
FOLEY, Corinne Nicole
TRAN, Anh Thu
description En el presente documento se describen compuestos que son inhibidores de al menos uno de ARG1 y ARG2 y composiciones que contienen los compuestos y métodos para sintetizar los compuestos. En el presente documento también se describe el uso de tales compuestos y composiciones para el tratamiento de una diversidad de enfermedades, trastornos y afecciones, incluidos los trastornos relacionados con el cáncer y con el sistema inmunitario que están mediados, al menos en parte, por ARG1 y ARG2. Compounds that are inhibitors of at least one of the ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Inhibidores de la arginasa
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