Compuestos, proceso de producción de compuestos, extracto enriquecido, fracciones activas de extracto enriquecido, proceso de producción de extracto enriquecido, método de selección de biomasa vegetal para la producción de extracto enriquecido, composición y uso para el tratamiento de trastornos inmunitarios

The invention describes novel and inventive isolated compounds and the process of producing compounds and extracts with immunosuppressive activity, from plants of the genus Stachytarpheta. In this way, the present application also describes novel and inventive compositions and its use for the treatm...

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Hauptverfasser: GUIMARÃES, Cristiano Ruch Werneck, VITOR, Carlos Eduardo, PESSA, Lisandra Ravanelli, MASCARELLO, Alessandra, REIS, Romulo Dragani, GAMA, Fernando Henrique De Souza
Format: Patent
Sprache:spa
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Zusammenfassung:The invention describes novel and inventive isolated compounds and the process of producing compounds and extracts with immunosuppressive activity, from plants of the genus Stachytarpheta. In this way, the present application also describes novel and inventive compositions and its use for the treatment of immunological disorders. The present invention is in the fields of pharmacy, medicine and chemistry. The present invention discloses enriched extracts from plants of the genus Stachytarpheta comprising ipolamiide and compounds of the formulae (I), (II) and/or (III):Such extracts could be useful to block activation of CD8+ T cells and reduce secretion of IFNgamma. They could have immunosuppressive activity and could be useful in methods of treatment of immunological disorders and vitiligo.Preferred compounds of formulae (I), (II) and (III) are compounds of the formulae (IV) to (XI):Additionally the extracts preferably contain also compounds of the formulae (XII) to (XVI):