Formas cristalinas de los análogos de sofosbuvir antivirales

FORMAS CRISTALINAS DE ANÁLOGOS DE SOFOSBUVIR; COMPOSICIÓN FARMACÉUTICA Y USO EN EL TRATAMIENTO DE LA HEPATITIS C. Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2- yl)methoxy...

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Hauptverfasser:	SEO MUN SIK, CASTEEL MELISSA JEAN, DASHNER KATHLEEN, SHI BING, ZIA VAHID, WANG FANG, JUNG HYUK-JUN
Format:	Patent
Sprache:	spa
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Zusammenfassung:	FORMAS CRISTALINAS DE ANÁLOGOS DE SOFOSBUVIR; COMPOSICIÓN FARMACÉUTICA Y USO EN EL TRATAMIENTO DE LA HEPATITIS C. Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2- yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I) are described Also provided are processes of making and methods of using the crystalline forms.