Compuestos derivados de aza adamantano, inhibidores de 11beta-hsd-1; composicion farmaceutica; metodo para prevencion o tratamiento; y uso para prevenir o tratar el sindrome metabolico, diabetes tipo 2 como consecuencia de obesidad, resisitencia a insulina, dislipidemia, neuropatia, isquemia e infarto, entre otras enfermedades
The present invention relates to certain amide derivatives that have the ability to inhibit 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the...
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| creator | MALLIKARJUNA, RAYI RAO, JAGANNATH MADANAHALLI RANGANATH MANIVANNAN, R JAGANNATH, S KUMAR B SIVA SENTHLL GEORGE, JENSON KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI DOPPALAPUDI, SIVANAGESWARA MALLIKARJUNA RAYI VENKATESHAM, UPPALA NAIDU, GORLE PAIDAPU FERNAND, GEORGE MADHAVAN, G R KADAMBARI, V.S. NAGA RAJESH KUMAR, T SENTHIL |
| description | The present invention relates to certain amide derivatives that have the ability to inhibit 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions. |
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It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141121&DB=EPODOC&CC=CL&NR=2014001705A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20141121&DB=EPODOC&CC=CL&NR=2014001705A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MALLIKARJUNA, RAYI</creatorcontrib><creatorcontrib>RAO, JAGANNATH MADANAHALLI RANGANATH</creatorcontrib><creatorcontrib>MANIVANNAN, R</creatorcontrib><creatorcontrib>JAGANNATH, S</creatorcontrib><creatorcontrib>KUMAR B SIVA SENTHLL</creatorcontrib><creatorcontrib>GEORGE, JENSON</creatorcontrib><creatorcontrib>KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI</creatorcontrib><creatorcontrib>DOPPALAPUDI, SIVANAGESWARA</creatorcontrib><creatorcontrib>MALLIKARJUNA RAYI</creatorcontrib><creatorcontrib>VENKATESHAM, UPPALA</creatorcontrib><creatorcontrib>NAIDU, GORLE PAIDAPU</creatorcontrib><creatorcontrib>FERNAND, GEORGE</creatorcontrib><creatorcontrib>MADHAVAN, G R</creatorcontrib><creatorcontrib>KADAMBARI, V.S. 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NAGA RAJESH</creatorcontrib><creatorcontrib>KUMAR, T SENTHIL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MALLIKARJUNA, RAYI</au><au>RAO, JAGANNATH MADANAHALLI RANGANATH</au><au>MANIVANNAN, R</au><au>JAGANNATH, S</au><au>KUMAR B SIVA SENTHLL</au><au>GEORGE, JENSON</au><au>KENCHEGOWDA, BOMMEGOWDA YADAGANAHALLI</au><au>DOPPALAPUDI, SIVANAGESWARA</au><au>MALLIKARJUNA RAYI</au><au>VENKATESHAM, UPPALA</au><au>NAIDU, GORLE PAIDAPU</au><au>FERNAND, GEORGE</au><au>MADHAVAN, G R</au><au>KADAMBARI, V.S. NAGA RAJESH</au><au>KUMAR, T SENTHIL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compuestos derivados de aza adamantano, inhibidores de 11beta-hsd-1; composicion farmaceutica; metodo para prevencion o tratamiento; y uso para prevenir o tratar el sindrome metabolico, diabetes tipo 2 como consecuencia de obesidad, resisitencia a insulina, dislipidemia, neuropatia, isquemia e infarto, entre otras enfermedades</title><date>2014-11-21</date><risdate>2014</risdate><abstract>The present invention relates to certain amide derivatives that have the ability to inhibit 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compuestos derivados de aza adamantano, inhibidores de 11beta-hsd-1; composicion farmaceutica; metodo para prevencion o tratamiento; y uso para prevenir o tratar el sindrome metabolico, diabetes tipo 2 como consecuencia de obesidad, resisitencia a insulina, dislipidemia, neuropatia, isquemia e infarto, entre otras enfermedades |
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