Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos
LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE AZETLDLN-2-ONA DE FÓRMULA 1 DONDE QUE RL, R2, R3, R4, RS Y R6 SON COMO SE DEFINEN EN PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN DE LOS MISMOS; COMPOSICIÓN FARMACÉUTICA; USO DE LOS COMPUESTOS EN LA REDUCCIÓN DE LOS NIVELES DE C...
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| creator | CHEN, YING BAI, HUA ZHAO, XUYANG XU, XIAOJIE LIU, XIAOYU ZHANG, YUNCAI ZHENG, XIAOHE GU, MAOJIAN ZHU, QIFENG ZHANG, YONG LOU, HAIRONG |
| description | LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE AZETLDLN-2-ONA DE FÓRMULA 1 DONDE QUE RL, R2, R3, R4, RS Y R6 SON COMO SE DEFINEN EN PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN DE LOS MISMOS;
COMPOSICIÓN FARMACÉUTICA; USO DE LOS COMPUESTOS EN LA REDUCCIÓN DE LOS NIVELES DE COLESTEROL TOTAL (CT) Y COLESTEROL DE LLPOPROTEÍNAS DE
BAJA DENSIDAD (LDL-C) EN PLASMA; COMPUESTOS INTERMEDIOS IV Y V Y PROCEDIMIENTO DE PREPARACIÓN DEL COMPUESTO INTERMEDIARIO V.
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CL2012000351A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CL2012000351A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CL2012000351A13</originalsourceid><addsrcrecordid>eNqNjr1LBEEMxc_C4lBL-4D1wu4eVlvJcmJhaX_kZrJcYGYyzoegf72ZRQ8RC6uEvJf3ftuL21l8rJSLZLCU-A3tugF-UGHLoRs7CTiBkQA1AC1kigCHEx_ZSoIsx0RATg1OYyiJmyAmMWTZMwU1R0yoJ2ozgdN8cy6dfuyaqv9eHzHxtySZDWv3gsmjoVrYILxWWsVEoaEqmDTm39HvUPMfAlAAdyZa09XTeg36RpyvN5cLukw3X_Nqc_e4f5mfOopyoBwVJFA5zM9jP4x93-_uh4dh9z_XJ7W_gbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos</title><source>esp@cenet</source><creator>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</creator><creatorcontrib>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</creatorcontrib><description>LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE AZETLDLN-2-ONA DE FÓRMULA 1 DONDE QUE RL, R2, R3, R4, RS Y R6 SON COMO SE DEFINEN EN PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN DE LOS MISMOS;
COMPOSICIÓN FARMACÉUTICA; USO DE LOS COMPUESTOS EN LA REDUCCIÓN DE LOS NIVELES DE COLESTEROL TOTAL (CT) Y COLESTEROL DE LLPOPROTEÍNAS DE
BAJA DENSIDAD (LDL-C) EN PLASMA; COMPUESTOS INTERMEDIOS IV Y V Y PROCEDIMIENTO DE PREPARACIÓN DEL COMPUESTO INTERMEDIARIO V.
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120810&DB=EPODOC&CC=CL&NR=2012000351A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120810&DB=EPODOC&CC=CL&NR=2012000351A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</creatorcontrib><title>Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos</title><description>LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE AZETLDLN-2-ONA DE FÓRMULA 1 DONDE QUE RL, R2, R3, R4, RS Y R6 SON COMO SE DEFINEN EN PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN DE LOS MISMOS;
COMPOSICIÓN FARMACÉUTICA; USO DE LOS COMPUESTOS EN LA REDUCCIÓN DE LOS NIVELES DE COLESTEROL TOTAL (CT) Y COLESTEROL DE LLPOPROTEÍNAS DE
BAJA DENSIDAD (LDL-C) EN PLASMA; COMPUESTOS INTERMEDIOS IV Y V Y PROCEDIMIENTO DE PREPARACIÓN DEL COMPUESTO INTERMEDIARIO V.
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjr1LBEEMxc_C4lBL-4D1wu4eVlvJcmJhaX_kZrJcYGYyzoegf72ZRQ8RC6uEvJf3ftuL21l8rJSLZLCU-A3tugF-UGHLoRs7CTiBkQA1AC1kigCHEx_ZSoIsx0RATg1OYyiJmyAmMWTZMwU1R0yoJ2ozgdN8cy6dfuyaqv9eHzHxtySZDWv3gsmjoVrYILxWWsVEoaEqmDTm39HvUPMfAlAAdyZa09XTeg36RpyvN5cLukw3X_Nqc_e4f5mfOopyoBwVJFA5zM9jP4x93-_uh4dh9z_XJ7W_gbg</recordid><startdate>20120810</startdate><enddate>20120810</enddate><creator>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</creator><scope>EVB</scope></search><sort><creationdate>20120810</creationdate><title>Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos</title><author>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CL2012000351A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN, YING; BAI, HUA; ZHAO, XUYANG; XU, XIAOJIE; LIU, XIAOYU; ZHANG, YUNCAI; ZHENG, XIAOHE; GU, MAOJIAN; ZHU, QIFENG; ZHANG, YONG; LOU, HAIRONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos</title><date>2012-08-10</date><risdate>2012</risdate><abstract>LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE AZETLDLN-2-ONA DE FÓRMULA 1 DONDE QUE RL, R2, R3, R4, RS Y R6 SON COMO SE DEFINEN EN PLIEGO DE REIVINDICACIONES; PROCEDIMIENTO DE PREPARACIÓN DE LOS MISMOS;
COMPOSICIÓN FARMACÉUTICA; USO DE LOS COMPUESTOS EN LA REDUCCIÓN DE LOS NIVELES DE COLESTEROL TOTAL (CT) Y COLESTEROL DE LLPOPROTEÍNAS DE
BAJA DENSIDAD (LDL-C) EN PLASMA; COMPUESTOS INTERMEDIOS IV Y V Y PROCEDIMIENTO DE PREPARACIÓN DEL COMPUESTO INTERMEDIARIO V.
Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compuestos derivados de azetidin-2-ona; con un efecto inhibidor sobre el colesterol; procedimiento para preparar los compuestos; compuestos intermediarios; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos |
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