COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA

Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
1. Verfasser:	ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR
description	Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CL2008000531A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CL2008000531A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CL2008000531A13</originalsourceid><addsrcrecordid>eNqNjk1LA0EMhvfiQdT_EPBaYWsRhJ5iJtsNzE7aTKbgqRRZT6KF-us9ObuIXj0l5ON53svmi3TYFs6uGQKb7DHMHfTsbEpCUfMCJPXyJEGN52VEwLxFc4lbU2fMuIaJpFlINEGHNiBxcSGEXeF5aZzqL0IQ6qvkz7yGZ8gFSlbgBBzBDR0H4eQ66Th1bAMHDFVPaEF0j5lKxJpnUUGbJF6j58pJXEwDbzhxhcxDx8izTqfgv7Dr5uL1-HYeb37qVXPbsVN_N54-DuP5dHwZ38fPA8X7tn1s2_ZhtcTl6n9X38HUXmo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA</title><source>esp@cenet</source><creator>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</creator><creatorcontrib>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</creatorcontrib><description>Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080922&DB=EPODOC&CC=CL&NR=2008000531A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20080922&DB=EPODOC&CC=CL&NR=2008000531A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</creatorcontrib><title>COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA</title><description>Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjk1LA0EMhvfiQdT_EPBaYWsRhJ5iJtsNzE7aTKbgqRRZT6KF-us9ObuIXj0l5ON53svmi3TYFs6uGQKb7DHMHfTsbEpCUfMCJPXyJEGN52VEwLxFc4lbU2fMuIaJpFlINEGHNiBxcSGEXeF5aZzqL0IQ6qvkz7yGZ8gFSlbgBBzBDR0H4eQ66Th1bAMHDFVPaEF0j5lKxJpnUUGbJF6j58pJXEwDbzhxhcxDx8izTqfgv7Dr5uL1-HYeb37qVXPbsVN_N54-DuP5dHwZ38fPA8X7tn1s2_ZhtcTl6n9X38HUXmo</recordid><startdate>20080922</startdate><enddate>20080922</enddate><creator>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</creator><scope>EVB</scope></search><sort><creationdate>20080922</creationdate><title>COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA</title><author>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CL2008000531A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHU ZHAONING,MACKITTRICK BRIAN,SUN ZHONG-YUE,YE YUANZAN C.,VOIGT JOHANNES H.,STRICKLAND COREY,SMITHELIZABETH M.,STAMFOR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA</title><date>2008-09-22</date><risdate>2008</risdate><abstract>Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	spa
recordid	cdi_epo_espacenet_CL2008000531A1
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	COMPUESTOS DERIVADOS DE HETEROCICLOS, INHIBIDORES DE LA ASPARTILPROTEASA; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, COGNITIVAS Y NEURODEGENERATIVAS TALES COMO LA ENFERMEDA
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T22%3A31%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ZHU%20ZHAONING,MACKITTRICK%20BRIAN,SUN%20ZHONG-YUE,YE%20YUANZAN%20C.,VOIGT%20JOHANNES%20H.,STRICKLAND%20COREY,SMITHELIZABETH%20M.,STAMFOR&rft.date=2008-09-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECL2008000531A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true