COMPUESTOS DERIVADOS DE IMIDAZOL CONDENSADOS, INHIBIDORES DEL FACTOR XA Y/O DEL FACTOR VLLA; COMPOSICION FARMACEUTICA; PROCESO DE PREPARACION; Y SU USO PARA TRATAR FIBRINOLISIS, LA FORMACION ANORMAL DE TROMBOS, INFARTO DE MIOCARDIO AGUDO, TRASTORNOS
Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R ; R ; R ; R ; R ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong an...
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creator | NAZARE MARC WAGNER MICHAEL WEHNER VOLKMAR MATTER HANS URMANN MATTHIAS RITTER KURT |
description | Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R ; R ; R ; R ; R ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them. |
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The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.</description><edition>7</edition><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050408&DB=EPODOC&CC=CL&NR=2004001078A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050408&DB=EPODOC&CC=CL&NR=2004001078A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAZARE MARC; WAGNER MICHAEL; WEHNER VOLKMAR; MATTER HANS; URMANN MATTHIAS; RITTER KURT</creatorcontrib><title>COMPUESTOS DERIVADOS DE IMIDAZOL CONDENSADOS, INHIBIDORES DEL FACTOR XA Y/O DEL FACTOR VLLA; COMPOSICION FARMACEUTICA; PROCESO DE PREPARACION; Y SU USO PARA TRATAR FIBRINOLISIS, LA FORMACION ANORMAL DE TROMBOS, INFARTO DE MIOCARDIO AGUDO, TRASTORNOS</title><description>Benzimidazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I, wherein R ; R ; R ; R ; R ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. 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The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | COMPUESTOS DERIVADOS DE IMIDAZOL CONDENSADOS, INHIBIDORES DEL FACTOR XA Y/O DEL FACTOR VLLA; COMPOSICION FARMACEUTICA; PROCESO DE PREPARACION; Y SU USO PARA TRATAR FIBRINOLISIS, LA FORMACION ANORMAL DE TROMBOS, INFARTO DE MIOCARDIO AGUDO, TRASTORNOS |
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