CH678726
PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate hav...
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creator | NIKOLAEVA, IRINA SERGEEVNA ZOTOVA, SVETLANA ALEXEEVNA BRYANTSEVA, ELENA ALEXEEVNA SAFONOVA, LJUDMILA SERGEEVNA PETERS, VALENTINA VASILIEVNA SHVETSOVA, EVGENIA GEORGIEVNA SAKHASCHIK, ZINAIDA MIKHAILOVNA SVIRINA, EVGENIA ALEXANDROVNA KUBAR, OLGA IOSIFOVNA BOGDANOVA, NADEZHDA SERGEEVNA YADROVSKAYA, VERA ALEXANDROVNA PERSHIN, GRIGORY NIKOLAEVICH ZLYDNIKOV, DMITRY MIKHAILOVICH KUTCHAK, SVETLANA NIKOLAEVNA TROFIMOV, FEDOR ALEXANDROVICH KONOPLYANNIKOV, ANATOLY GEORGIEVICH PADEISKAYA, ELENA NIKOLAEVNA FOMINA, ALLA NIKOLAEVNA GRINEV, ALEXEI NIKOLAEVICH SURINOV, BORIS PAVLOVICH SAVINOVA, LJUDMILA ALEXEEVNA KARPOVA, NINA ALEXEEVNA TSYSHKOVA, NINA GAVRILOVNA SAVINA, ELENA PETROVNA |
description | PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate having the following formula: A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65 DEG C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, interferon-inducing and immunomodulatory effects. |
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fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CH678726A5</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CH678726A5</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CH678726A53</originalsourceid><addsrcrecordid>eNrjZOBw9jAztzA3MuNhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfEw5Y6mxoRVAACPZhoA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CH678726</title><source>esp@cenet</source><creator>NIKOLAEVA, IRINA SERGEEVNA ; ZOTOVA, SVETLANA ALEXEEVNA ; BRYANTSEVA, ELENA ALEXEEVNA ; SAFONOVA, LJUDMILA SERGEEVNA ; PETERS, VALENTINA VASILIEVNA ; SHVETSOVA, EVGENIA GEORGIEVNA ; SAKHASCHIK, ZINAIDA MIKHAILOVNA ; SVIRINA, EVGENIA ALEXANDROVNA ; KUBAR, OLGA IOSIFOVNA ; BOGDANOVA, NADEZHDA SERGEEVNA ; YADROVSKAYA, VERA ALEXANDROVNA ; PERSHIN, GRIGORY NIKOLAEVICH ; ZLYDNIKOV, DMITRY MIKHAILOVICH ; KUTCHAK, SVETLANA NIKOLAEVNA ; TROFIMOV, FEDOR ALEXANDROVICH ; KONOPLYANNIKOV, ANATOLY GEORGIEVICH ; PADEISKAYA, ELENA NIKOLAEVNA ; FOMINA, ALLA NIKOLAEVNA ; GRINEV, ALEXEI NIKOLAEVICH ; SURINOV, BORIS PAVLOVICH ; SAVINOVA, LJUDMILA ALEXEEVNA ; KARPOVA, NINA ALEXEEVNA ; TSYSHKOVA, NINA GAVRILOVNA ; SAVINA, ELENA PETROVNA</creator><creatorcontrib>NIKOLAEVA, IRINA SERGEEVNA ; ZOTOVA, SVETLANA ALEXEEVNA ; BRYANTSEVA, ELENA ALEXEEVNA ; SAFONOVA, LJUDMILA SERGEEVNA ; PETERS, VALENTINA VASILIEVNA ; SHVETSOVA, EVGENIA GEORGIEVNA ; SAKHASCHIK, ZINAIDA MIKHAILOVNA ; SVIRINA, EVGENIA ALEXANDROVNA ; KUBAR, OLGA IOSIFOVNA ; BOGDANOVA, NADEZHDA SERGEEVNA ; YADROVSKAYA, VERA ALEXANDROVNA ; PERSHIN, GRIGORY NIKOLAEVICH ; ZLYDNIKOV, DMITRY MIKHAILOVICH ; KUTCHAK, SVETLANA NIKOLAEVNA ; TROFIMOV, FEDOR ALEXANDROVICH ; KONOPLYANNIKOV, ANATOLY GEORGIEVICH ; PADEISKAYA, ELENA NIKOLAEVNA ; FOMINA, ALLA NIKOLAEVNA ; GRINEV, ALEXEI NIKOLAEVICH ; SURINOV, BORIS PAVLOVICH ; SAVINOVA, LJUDMILA ALEXEEVNA ; KARPOVA, NINA ALEXEEVNA ; TSYSHKOVA, NINA GAVRILOVNA ; SAVINA, ELENA PETROVNA</creatorcontrib><description>PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate having the following formula: A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65 DEG C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, interferon-inducing and immunomodulatory effects.</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911031&DB=EPODOC&CC=CH&NR=678726A5$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19911031&DB=EPODOC&CC=CH&NR=678726A5$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NIKOLAEVA, IRINA SERGEEVNA</creatorcontrib><creatorcontrib>ZOTOVA, SVETLANA ALEXEEVNA</creatorcontrib><creatorcontrib>BRYANTSEVA, ELENA ALEXEEVNA</creatorcontrib><creatorcontrib>SAFONOVA, LJUDMILA SERGEEVNA</creatorcontrib><creatorcontrib>PETERS, VALENTINA VASILIEVNA</creatorcontrib><creatorcontrib>SHVETSOVA, EVGENIA GEORGIEVNA</creatorcontrib><creatorcontrib>SAKHASCHIK, ZINAIDA MIKHAILOVNA</creatorcontrib><creatorcontrib>SVIRINA, EVGENIA ALEXANDROVNA</creatorcontrib><creatorcontrib>KUBAR, OLGA IOSIFOVNA</creatorcontrib><creatorcontrib>BOGDANOVA, NADEZHDA SERGEEVNA</creatorcontrib><creatorcontrib>YADROVSKAYA, VERA ALEXANDROVNA</creatorcontrib><creatorcontrib>PERSHIN, GRIGORY NIKOLAEVICH</creatorcontrib><creatorcontrib>ZLYDNIKOV, DMITRY MIKHAILOVICH</creatorcontrib><creatorcontrib>KUTCHAK, SVETLANA NIKOLAEVNA</creatorcontrib><creatorcontrib>TROFIMOV, FEDOR ALEXANDROVICH</creatorcontrib><creatorcontrib>KONOPLYANNIKOV, ANATOLY GEORGIEVICH</creatorcontrib><creatorcontrib>PADEISKAYA, ELENA NIKOLAEVNA</creatorcontrib><creatorcontrib>FOMINA, ALLA NIKOLAEVNA</creatorcontrib><creatorcontrib>GRINEV, ALEXEI NIKOLAEVICH</creatorcontrib><creatorcontrib>SURINOV, BORIS PAVLOVICH</creatorcontrib><creatorcontrib>SAVINOVA, LJUDMILA ALEXEEVNA</creatorcontrib><creatorcontrib>KARPOVA, NINA ALEXEEVNA</creatorcontrib><creatorcontrib>TSYSHKOVA, NINA GAVRILOVNA</creatorcontrib><creatorcontrib>SAVINA, ELENA PETROVNA</creatorcontrib><title>CH678726</title><description>PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate having the following formula: A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65 DEG C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, interferon-inducing and immunomodulatory effects.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOBw9jAztzA3MuNhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfEw5Y6mxoRVAACPZhoA</recordid><startdate>19911031</startdate><enddate>19911031</enddate><creator>NIKOLAEVA, IRINA SERGEEVNA</creator><creator>ZOTOVA, SVETLANA ALEXEEVNA</creator><creator>BRYANTSEVA, ELENA ALEXEEVNA</creator><creator>SAFONOVA, LJUDMILA SERGEEVNA</creator><creator>PETERS, VALENTINA VASILIEVNA</creator><creator>SHVETSOVA, EVGENIA GEORGIEVNA</creator><creator>SAKHASCHIK, ZINAIDA MIKHAILOVNA</creator><creator>SVIRINA, EVGENIA ALEXANDROVNA</creator><creator>KUBAR, OLGA IOSIFOVNA</creator><creator>BOGDANOVA, NADEZHDA SERGEEVNA</creator><creator>YADROVSKAYA, VERA ALEXANDROVNA</creator><creator>PERSHIN, GRIGORY NIKOLAEVICH</creator><creator>ZLYDNIKOV, DMITRY MIKHAILOVICH</creator><creator>KUTCHAK, SVETLANA NIKOLAEVNA</creator><creator>TROFIMOV, FEDOR ALEXANDROVICH</creator><creator>KONOPLYANNIKOV, ANATOLY GEORGIEVICH</creator><creator>PADEISKAYA, ELENA NIKOLAEVNA</creator><creator>FOMINA, ALLA NIKOLAEVNA</creator><creator>GRINEV, ALEXEI NIKOLAEVICH</creator><creator>SURINOV, BORIS PAVLOVICH</creator><creator>SAVINOVA, LJUDMILA ALEXEEVNA</creator><creator>KARPOVA, NINA ALEXEEVNA</creator><creator>TSYSHKOVA, NINA GAVRILOVNA</creator><creator>SAVINA, ELENA PETROVNA</creator><scope>EVB</scope></search><sort><creationdate>19911031</creationdate><title>CH678726</title><author>NIKOLAEVA, IRINA SERGEEVNA ; ZOTOVA, SVETLANA ALEXEEVNA ; BRYANTSEVA, ELENA ALEXEEVNA ; SAFONOVA, LJUDMILA SERGEEVNA ; PETERS, VALENTINA VASILIEVNA ; SHVETSOVA, EVGENIA GEORGIEVNA ; SAKHASCHIK, ZINAIDA MIKHAILOVNA ; SVIRINA, EVGENIA ALEXANDROVNA ; KUBAR, OLGA IOSIFOVNA ; BOGDANOVA, NADEZHDA SERGEEVNA ; YADROVSKAYA, VERA ALEXANDROVNA ; PERSHIN, GRIGORY NIKOLAEVICH ; ZLYDNIKOV, DMITRY MIKHAILOVICH ; KUTCHAK, SVETLANA NIKOLAEVNA ; TROFIMOV, FEDOR ALEXANDROVICH ; KONOPLYANNIKOV, ANATOLY GEORGIEVICH ; PADEISKAYA, ELENA NIKOLAEVNA ; FOMINA, ALLA NIKOLAEVNA ; GRINEV, ALEXEI NIKOLAEVICH ; SURINOV, BORIS PAVLOVICH ; SAVINOVA, LJUDMILA ALEXEEVNA ; KARPOVA, NINA ALEXEEVNA ; TSYSHKOVA, NINA GAVRILOVNA ; SAVINA, ELENA PETROVNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CH678726A53</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1991</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NIKOLAEVA, IRINA SERGEEVNA</creatorcontrib><creatorcontrib>ZOTOVA, SVETLANA ALEXEEVNA</creatorcontrib><creatorcontrib>BRYANTSEVA, ELENA ALEXEEVNA</creatorcontrib><creatorcontrib>SAFONOVA, LJUDMILA SERGEEVNA</creatorcontrib><creatorcontrib>PETERS, VALENTINA VASILIEVNA</creatorcontrib><creatorcontrib>SHVETSOVA, EVGENIA GEORGIEVNA</creatorcontrib><creatorcontrib>SAKHASCHIK, ZINAIDA MIKHAILOVNA</creatorcontrib><creatorcontrib>SVIRINA, EVGENIA ALEXANDROVNA</creatorcontrib><creatorcontrib>KUBAR, OLGA IOSIFOVNA</creatorcontrib><creatorcontrib>BOGDANOVA, NADEZHDA SERGEEVNA</creatorcontrib><creatorcontrib>YADROVSKAYA, VERA ALEXANDROVNA</creatorcontrib><creatorcontrib>PERSHIN, GRIGORY NIKOLAEVICH</creatorcontrib><creatorcontrib>ZLYDNIKOV, DMITRY MIKHAILOVICH</creatorcontrib><creatorcontrib>KUTCHAK, SVETLANA NIKOLAEVNA</creatorcontrib><creatorcontrib>TROFIMOV, FEDOR ALEXANDROVICH</creatorcontrib><creatorcontrib>KONOPLYANNIKOV, ANATOLY GEORGIEVICH</creatorcontrib><creatorcontrib>PADEISKAYA, ELENA NIKOLAEVNA</creatorcontrib><creatorcontrib>FOMINA, ALLA NIKOLAEVNA</creatorcontrib><creatorcontrib>GRINEV, ALEXEI NIKOLAEVICH</creatorcontrib><creatorcontrib>SURINOV, BORIS PAVLOVICH</creatorcontrib><creatorcontrib>SAVINOVA, LJUDMILA ALEXEEVNA</creatorcontrib><creatorcontrib>KARPOVA, NINA ALEXEEVNA</creatorcontrib><creatorcontrib>TSYSHKOVA, NINA GAVRILOVNA</creatorcontrib><creatorcontrib>SAVINA, ELENA PETROVNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NIKOLAEVA, IRINA SERGEEVNA</au><au>ZOTOVA, SVETLANA ALEXEEVNA</au><au>BRYANTSEVA, ELENA ALEXEEVNA</au><au>SAFONOVA, LJUDMILA SERGEEVNA</au><au>PETERS, VALENTINA VASILIEVNA</au><au>SHVETSOVA, EVGENIA GEORGIEVNA</au><au>SAKHASCHIK, ZINAIDA MIKHAILOVNA</au><au>SVIRINA, EVGENIA ALEXANDROVNA</au><au>KUBAR, OLGA IOSIFOVNA</au><au>BOGDANOVA, NADEZHDA SERGEEVNA</au><au>YADROVSKAYA, VERA ALEXANDROVNA</au><au>PERSHIN, GRIGORY NIKOLAEVICH</au><au>ZLYDNIKOV, DMITRY MIKHAILOVICH</au><au>KUTCHAK, SVETLANA NIKOLAEVNA</au><au>TROFIMOV, FEDOR ALEXANDROVICH</au><au>KONOPLYANNIKOV, ANATOLY GEORGIEVICH</au><au>PADEISKAYA, ELENA NIKOLAEVNA</au><au>FOMINA, ALLA NIKOLAEVNA</au><au>GRINEV, ALEXEI NIKOLAEVICH</au><au>SURINOV, BORIS PAVLOVICH</au><au>SAVINOVA, LJUDMILA ALEXEEVNA</au><au>KARPOVA, NINA ALEXEEVNA</au><au>TSYSHKOVA, NINA GAVRILOVNA</au><au>SAVINA, ELENA PETROVNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CH678726</title><date>1991-10-31</date><risdate>1991</risdate><abstract>PCT No. PCT/SU89/00272 Sec. 371 Date Nov. 12, 1991 Sec. 102(e) Date Nov. 12, 1991 PCT Filed Jan. 12, 1989 PCT Pub. No. WO90/08135 PCT Pub. Date Jul. 26, 1990.A novel compound-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate hydrochloride monohydrate having the following formula: A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65 DEG C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base-ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylind ole-3- carboxylate. The compound according to the invention is an active principle of a pharmaceutical preparation having the antiviral, interferon-inducing and immunomodulatory effects.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | CH678726 |
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