Process for the preparation of anthracycline antibiotics with anticancer activity, and microorganism strain as means for the preparation

The antibiotics aclacinomycin A and B which have anticancer activity, and mixtures thereof, are obtained by cultivation of the strain 12/3-A of Streptomyces lavendofoliae under aerobic conditions in a nutrient medium which contains carbon- and nitrogen-containing compounds at a temperature of 20 - 3...

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Hauptverfasser:	FOMINA, INESSA PETROVNA, KRJUCHKOVA, ELENA IVANOVNA, TERENTIEVA, TATYANA GEORGIEVNA, TAIG, MARIA MIRONOVNA, EGOROV, LEV VLADIMIROVICH, VESELOVA, SVETLANA IVANOVNA, ESIPOV, STANISLAV EMELYANOVICH, SOIFER, VLADIMIR SOLOMONOVICH, KLJUEV, NIKOLAI ALEXEEVICH, NAVASHIN, SERGEI MIKHAILOVICH, IVANITSKAYA, LJUDMILA PETROVNA, SINGAL, EMILIA MOISEEVNA, OSTANINA, LJUDMILA NIKOLAEVNA, CHERNYSHEV, ALEXEI IVANOVICH
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The antibiotics aclacinomycin A and B which have anticancer activity, and mixtures thereof, are obtained by cultivation of the strain 12/3-A of Streptomyces lavendofoliae under aerobic conditions in a nutrient medium which contains carbon- and nitrogen-containing compounds at a temperature of 20 - 30 DEG C and at a pH of 6 - 8.5 for 48 - 96 h.