CH616946

Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of X1 to X4 is selected from the group consisting of mercapto and...

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Hauptverfasser:	GYOERGY BEER, LASZLO SZPORNY, SZABOLCS SZEBERENYI, ANTAL DUDAS, TIBOR KEKESY, EVA CZAJLIK-CSIZER, GYOERGY HAJOS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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creator	GYOERGY BEER LASZLO SZPORNY SZABOLCS SZEBERENYI ANTAL DUDAS TIBOR KEKESY EVA CZAJLIK-CSIZER GYOERGY HAJOS
description	Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of X1 to X4 is selected from the group consisting of mercapto and acetylthio. The compounds are prepared as follows: a compound of the formula (III) wherein Z1 is hydrogen and Z2 is hydrogen or acetylthio or Z1 and Z2 form together a valence bond, is brominated, the thus-obtained compound of the formula WHEREIN Y1 and Y2 each is hydrogen or bromine, Y3 is bromine, Y4 is hydrogen or acetylthio or Y3 and Y4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.
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The compounds are prepared as follows: a compound of the formula (III) wherein Z1 is hydrogen and Z2 is hydrogen or acetylthio or Z1 and Z2 form together a valence bond, is brominated, the thus-obtained compound of the formula WHEREIN Y1 and Y2 each is hydrogen or bromine, Y3 is bromine, Y4 is hydrogen or acetylthio or Y3 and Y4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>1980</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19800430&DB=EPODOC&CC=CH&NR=616946A5$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19800430&DB=EPODOC&CC=CH&NR=616946A5$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GYOERGY BEER</creatorcontrib><creatorcontrib>LASZLO SZPORNY</creatorcontrib><creatorcontrib>SZABOLCS SZEBERENYI</creatorcontrib><creatorcontrib>ANTAL DUDAS</creatorcontrib><creatorcontrib>TIBOR KEKESY</creatorcontrib><creatorcontrib>EVA CZAJLIK-CSIZER</creatorcontrib><creatorcontrib>GYOERGY HAJOS</creatorcontrib><title>CH616946</title><description>Pharmaceutically active steroids of the formula (I) wherein X1 and X2 each is hydrogen, mercapto or acetylthio and X3 and X4 each is hydrogen or acetylthio or X3 and X4 form together a valence bond, with the proviso that at least one of X1 to X4 is selected from the group consisting of mercapto and acetylthio. The compounds are prepared as follows: a compound of the formula (III) wherein Z1 is hydrogen and Z2 is hydrogen or acetylthio or Z1 and Z2 form together a valence bond, is brominated, the thus-obtained compound of the formula WHEREIN Y1 and Y2 each is hydrogen or bromine, Y3 is bromine, Y4 is hydrogen or acetylthio or Y3 and Y4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. 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The compounds are prepared as follows: a compound of the formula (III) wherein Z1 is hydrogen and Z2 is hydrogen or acetylthio or Z1 and Z2 form together a valence bond, is brominated, the thus-obtained compound of the formula WHEREIN Y1 and Y2 each is hydrogen or bromine, Y3 is bromine, Y4 is hydrogen or acetylthio or Y3 and Y4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
title	CH616946
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