Process for the preparation of novel N-(p-fluorobenzoylpropyl)-4-piperidylamids

Novel N-(p-fluorobenzoylpropyl)-4-piperidyl-amides of the formula I shown, wherein R denotes a hydrogen atom, a straight-chain or branched alkyl radical having 1 to 15 carbon atoms, or a tetrahydrofuryl, furyl, thienyl, phenyl or adamantyl radical, are prepared by reacting 4-(4'-aminopiperidino)-p-fluorobutyrophenone with a carboxylic acid which introduces the group R, or with a functional derivative of such an acid, preferably an acid halide, especially the acid chloride, or an acid anhydride. In the case of the functional derivatives, the reaction is advantageously carried out in the presence of an acid-binding agent and in the case of the free carboxylic acid it is preferably carried out in the presence of a dehydrating condensation agent. The products of the process can be converted into their physiologically harmless acid addition salts. The novel compounds show the typical pattern of action of neuroleptics and can therefore be employed as central nervous system-damping (suppressing) agents, sedatives and tranquillisers.