Procédé de préparation des esters de la diméthylsulfamoyl-3 hydroxyéthylpipéridinopropyl-10 phénothiazine

1279595 Phenothiazines RHONE-POULENCSA 18 Nov 1970 [19 Nov 1969] 54918/70 Heading C2C Compounds of the general Formula (I): (where n is 6-34) and their acid addition salts are prepared either by reacting a compound of the Formula (II): where Y is OH with a compound (III) : where X is a radical which may react with an OH group to form HX (e.g. Hal, OH, O-Alkyl or imidazolyl) or by reacting (II) where Y is an acid residue of a reactive ester (e.g. halogen or a sulphuric or sulphonic ester residue) with a compound (III) where X is OH. Compounds ClCO(CH 2 ) n COCl where n is 11, 12, 14, 16, 17 and 34 are prepared from the corresponding acid and SOCl 2 . Pharmaceutical compositions useful as long acting neuroleptics, anti-emetics and tranquillizers contain (I) and a diluent in forms for parenteral, esp. intramuscular or subcutaneous administration.