Verfahren zur Herstellung von N-(3-Pyrrolidinyl)-phthalimiden

1,141,266. Novel N-substituted phthalimides. A. H. ROBINS CO. Inc. 30 Aug., 1966 [6 Dot., 1965], No. 38636/66. Heading C2C. Novel N-substituted phthalimides of the general formula wherein R is hydrogen, or a C 1-4 alkyl, aryl aralkyl or alicyclic group; R1 is hydrogen or a C 1-4 alkyl group; R11 is hydrogen, a halogen having an atomic weight less than 80, or a trifluoromethyl, C 1-4 alkyl or C 1-4 alkoxy group; m is 1 or 2 and n is from 1 to 4; and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof are prepared by reaction of a 3-halopyrrolidine or 3-pyrrolidinyl arylsulphonate and an alkali metal salt of a phthalimide of the corresponding formulae wherein M is an alkali metal and Y is a halogen atom or an arylsulphonate group, followed optionally by conversion of the product to a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof. Pharmaceutical compositions having antiarrhythmic activity comprise as active ingredient at least one N-substituted phthalimide of the first general formula above or pharmaceutically acceptable acid addition or quaternary ammonium salt thereof in association with a pharmaceutical carrier or excipient.