Verfahren zur Herstellung von Tetracyklin
Tetracycline is produced by cultivating a tetracycline- and chlortetracycline-producing strain of a species of Streptomyces in a conventional aqueous medium containing as chlorination inhibitor a 1,2,4-triazine of formula wherein X is hydrogen or C1- 6 alkyl; Z is hydrogen, C1- 6 alkyl, C1- 6 alken...
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| creator | SLEZAK,JOSEF CULIK,KAREL,RNDR VONDRACEK,MILOSLAV,RNDR HEROLD,MILOS |
| description | Tetracycline is produced by cultivating a tetracycline- and chlortetracycline-producing strain of a species of Streptomyces in a conventional aqueous medium containing as chlorination inhibitor a 1,2,4-triazine of formula wherein X is hydrogen or C1- 6 alkyl; Z is hydrogen, C1- 6 alkyl, C1- 6 alkenyl, aryl, aralkyl, -CH=CH.C6H5, -(CH2)nCOOH or -(CH2)n CONH2 where n = 0 to 7; Y is H, C1- 6 alkyl, aryl, aralkyl, -OH, -SH or NH2. Specified compounds are 3-methylmercapto-5-hydroxy- 6 - benzyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxamido - 1,2,4 - triazine, beta - (3 - mercapto- 5 - hydroxy - 1,2,4 - triazine - 6 -) propionic acid, 3 - mercapto - 5,6 - diphenyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - methyl-1,2,4 - triazine and 3 - mercapto - 5 - hydroxy- 6 - benzyl - 1,2,4 - triazine. The cultivation may also take place in the presence of bromine ions. |
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Specified compounds are 3-methylmercapto-5-hydroxy- 6 - benzyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxamido - 1,2,4 - triazine, beta - (3 - mercapto- 5 - hydroxy - 1,2,4 - triazine - 6 -) propionic acid, 3 - mercapto - 5,6 - diphenyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - methyl-1,2,4 - triazine and 3 - mercapto - 5 - hydroxy- 6 - benzyl - 1,2,4 - triazine. The cultivation may also take place in the presence of bromine ions.</description><edition>1</edition><language>ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1967</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19670930&DB=EPODOC&CC=CH&NR=444383A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19670930&DB=EPODOC&CC=CH&NR=444383A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SLEZAK,JOSEF</creatorcontrib><creatorcontrib>CULIK,KAREL,RNDR</creatorcontrib><creatorcontrib>VONDRACEK,MILOSLAV,RNDR</creatorcontrib><creatorcontrib>HEROLD,MILOS</creatorcontrib><title>Verfahren zur Herstellung von Tetracyklin</title><description>Tetracycline is produced by cultivating a tetracycline- and chlortetracycline-producing strain of a species of Streptomyces in a conventional aqueous medium containing as chlorination inhibitor a 1,2,4-triazine of formula <FORM:1073047/C2/1> wherein X is hydrogen or C1- 6 alkyl; Z is hydrogen, C1- 6 alkyl, C1- 6 alkenyl, aryl, aralkyl, -CH=CH.C6H5, -(CH2)nCOOH or -(CH2)n CONH2 where n = 0 to 7; Y is H, C1- 6 alkyl, aryl, aralkyl, -OH, -SH or NH2. Specified compounds are 3-methylmercapto-5-hydroxy- 6 - benzyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxamido - 1,2,4 - triazine, beta - (3 - mercapto- 5 - hydroxy - 1,2,4 - triazine - 6 -) propionic acid, 3 - mercapto - 5,6 - diphenyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - methyl-1,2,4 - triazine and 3 - mercapto - 5 - hydroxy- 6 - benzyl - 1,2,4 - triazine. 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Specified compounds are 3-methylmercapto-5-hydroxy- 6 - benzyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxy - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - carboxamido - 1,2,4 - triazine, beta - (3 - mercapto- 5 - hydroxy - 1,2,4 - triazine - 6 -) propionic acid, 3 - mercapto - 5,6 - diphenyl - 1,2,4 - triazine, 3 - mercapto - 5 - hydroxy - 6 - methyl-1,2,4 - triazine and 3 - mercapto - 5 - hydroxy- 6 - benzyl - 1,2,4 - triazine. The cultivation may also take place in the presence of bromine ions.</abstract><edition>1</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
| title | Verfahren zur Herstellung von Tetracyklin |
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