Procédé de préparation de composés organiques de l'aluminium

Polymeric aluminium compounds tending to the formula (XAlO)p where p is a large integer and X is a salicylate, substituted salicylate, barbiturate, substituted barbiturate, lactate, ascorbate, acetanilide phenacetin, testosterone, chloral hydrate, tribromoethanol, trichloro-tert-butanol, penicillin, aureomycin, nicotinate, nicotinamide, ephedrine, adrenaline or atropine radical or radical derived therefrom, is prepared by heating a polyoxo aluminium alkoxide, obtained by reacting an aluminium alcoholate with water until two moles of the alcohol corresponding to the alcoholate have been liberated per mole of water added, with any one of the above mentioned compounds. Examples are given of compounds where X is derived from acetylsalicylic acid, barbituric acid, ephedrine oxide, nicotinic acid, trichloro-tert-butoxide and p-aminosalicylic acid. Specification 825,878 is referred to.ALSO:The invention comprises aluminium compounds of the formula (Y2AlO2)(XAlO2)p(AlY2) where X is a salicylate, acetylsalicylate, p-amino salicylate, nicotinate, trichloro-tert-butoxide, chloral hydrate, ascorbate, penicillinate, aureomycin, ephedrine oxide, barbiturate or hydroxyl radical, Y is X or a hydroxyl radical (provided that both X and Y cannot represent hydroxyl groups), and p is a whole number from 1 upwards, and the preparation of pharmaceutically active aluminium compounds, comprising either heating an aluminium alcoholate with water and a substance selected from the group consisting of salicyclic acid, substituted salicyclic acids such as asprin, p-aminosalicylic acid, esters of salicylic acid, barbituric acid, substituted barbituric acids, lactic acid, ascorbic acid, acetanilide, phenacetin, testosterone chloral hydrate, tribromoethanol, trichloro-tert-butanol, penicillin, nicotinic acid, nicotinamide, ephedrine, adrenoline and atropine, until a polymeric aluminium compound is obtained, or heating a polyoxo aluminium alkoxide, obtained by reacting an aluminium alcoholate with water until two moles of the alcohol corresponding to the alcoholate have been liberated per mole of water added with one of the group of substances listed above, until a polymeric aluminium compound free from alkoxy groups is obtained (see also Group IV (a)). Specification 825,878 is referred to.