METHODS AND COMPOSITIONS FOR IMPROVING ENDOTHELIAL CELL BARRIER
Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may...
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| creator | GOOR, LOTTE VAN DEN FIORET, BRYAN PETERSEN, THOMAS GRAHAM, DAVID BONVILLAIN, RYAN VU, PETER |
| description | Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may include at least one or more of the following: an adenylyl cyclase activator; an activator of Sphingosine- 1 -phosphate (SIP) receptor internalization; a direct or indirect inducer of tight junction protein expression, and a direct or indirect inducer of adherens junction protein expression.
La présente invention concerne des procédés et des compositions destinés à améliorer la barrière vasculaire des cellules endothéliales. Les procédés peuvent comprendre l'utilisation de composés agonistes de barrière et de techniques améliorées pour la culture de cellules endothéliales. Les procédés et compositions améliorés pour la culture des cellules endothéliales peuvent inclure au moins un ou plusieurs des éléments suivants : un activateur de l'adénylyl cyclase; un activateur de l'internalisation du récepteur Sphingosine-1-phosphate (SIP); un inducteur direct ou indirect de l'expression de la protéine de la jonction serrée, et un inducteur direct ou indirect de l'expression de la protéine de la jonction d'adhérence. |
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La présente invention concerne des procédés et des compositions destinés à améliorer la barrière vasculaire des cellules endothéliales. Les procédés peuvent comprendre l'utilisation de composés agonistes de barrière et de techniques améliorées pour la culture de cellules endothéliales. Les procédés et compositions améliorés pour la culture des cellules endothéliales peuvent inclure au moins un ou plusieurs des éléments suivants : un activateur de l'adénylyl cyclase; un activateur de l'internalisation du récepteur Sphingosine-1-phosphate (SIP); un inducteur direct ou indirect de l'expression de la protéine de la jonction serrée, et un inducteur direct ou indirect de l'expression de la protéine de la jonction d'adhérence.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230615&DB=EPODOC&CC=CA&NR=3240212A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230615&DB=EPODOC&CC=CA&NR=3240212A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GOOR, LOTTE VAN DEN</creatorcontrib><creatorcontrib>FIORET, BRYAN</creatorcontrib><creatorcontrib>PETERSEN, THOMAS</creatorcontrib><creatorcontrib>GRAHAM, DAVID</creatorcontrib><creatorcontrib>BONVILLAIN, RYAN</creatorcontrib><creatorcontrib>VU, PETER</creatorcontrib><title>METHODS AND COMPOSITIONS FOR IMPROVING ENDOTHELIAL CELL BARRIER</title><description>Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may include at least one or more of the following: an adenylyl cyclase activator; an activator of Sphingosine- 1 -phosphate (SIP) receptor internalization; a direct or indirect inducer of tight junction protein expression, and a direct or indirect inducer of adherens junction protein expression.
La présente invention concerne des procédés et des compositions destinés à améliorer la barrière vasculaire des cellules endothéliales. Les procédés peuvent comprendre l'utilisation de composés agonistes de barrière et de techniques améliorées pour la culture de cellules endothéliales. Les procédés et compositions améliorés pour la culture des cellules endothéliales peuvent inclure au moins un ou plusieurs des éléments suivants : un activateur de l'adénylyl cyclase; un activateur de l'internalisation du récepteur Sphingosine-1-phosphate (SIP); un inducteur direct ou indirect de l'expression de la protéine de la jonction serrée, et un inducteur direct ou indirect de l'expression de la protéine de la jonction d'adhérence.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD3dQ3x8HcJVnD0c1Fw9vcN8A_2DPH09wtWcPMPUvD0DQjyD_P0c1dw9XPxD_Fw9fF09FFwdvXxUXByDArydA3iYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo7GRiYGRoZGjobGRCgBAD90Keg</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>GOOR, LOTTE VAN DEN</creator><creator>FIORET, BRYAN</creator><creator>PETERSEN, THOMAS</creator><creator>GRAHAM, DAVID</creator><creator>BONVILLAIN, RYAN</creator><creator>VU, PETER</creator><scope>EVB</scope></search><sort><creationdate>20230615</creationdate><title>METHODS AND COMPOSITIONS FOR IMPROVING ENDOTHELIAL CELL BARRIER</title><author>GOOR, LOTTE VAN DEN ; FIORET, BRYAN ; PETERSEN, THOMAS ; GRAHAM, DAVID ; BONVILLAIN, RYAN ; VU, PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3240212A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GOOR, LOTTE VAN DEN</creatorcontrib><creatorcontrib>FIORET, BRYAN</creatorcontrib><creatorcontrib>PETERSEN, THOMAS</creatorcontrib><creatorcontrib>GRAHAM, DAVID</creatorcontrib><creatorcontrib>BONVILLAIN, RYAN</creatorcontrib><creatorcontrib>VU, PETER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GOOR, LOTTE VAN DEN</au><au>FIORET, BRYAN</au><au>PETERSEN, THOMAS</au><au>GRAHAM, DAVID</au><au>BONVILLAIN, RYAN</au><au>VU, PETER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS AND COMPOSITIONS FOR IMPROVING ENDOTHELIAL CELL BARRIER</title><date>2023-06-15</date><risdate>2023</risdate><abstract>Described herein are methods and compositions for use in improving a vascular barrier of endothelial cells. The methods may include the use of barrier agonist compounds and improved techniques for culturing endothelial cells. The improved methods and compositions for culturing endothelial cells may include at least one or more of the following: an adenylyl cyclase activator; an activator of Sphingosine- 1 -phosphate (SIP) receptor internalization; a direct or indirect inducer of tight junction protein expression, and a direct or indirect inducer of adherens junction protein expression.
La présente invention concerne des procédés et des compositions destinés à améliorer la barrière vasculaire des cellules endothéliales. Les procédés peuvent comprendre l'utilisation de composés agonistes de barrière et de techniques améliorées pour la culture de cellules endothéliales. Les procédés et compositions améliorés pour la culture des cellules endothéliales peuvent inclure au moins un ou plusieurs des éléments suivants : un activateur de l'adénylyl cyclase; un activateur de l'internalisation du récepteur Sphingosine-1-phosphate (SIP); un inducteur direct ou indirect de l'expression de la protéine de la jonction serrée, et un inducteur direct ou indirect de l'expression de la protéine de la jonction d'adhérence.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHODS AND COMPOSITIONS FOR IMPROVING ENDOTHELIAL CELL BARRIER |
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