AQUEOUS FORMULATIONS OF AN ANTI-CD22 ANTIBODY AND USES THEREOF

A stable pharmaceutical formulation of a therapeutically active anti-CD22 antibody, Suciraslimab (or SM03), for injection. In particular, the formulations comprising, in addition to a suitable amount of the anti-CD22 antibody.The formulations comprise additionally at least one buffering agent, such...

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Hauptverfasser: SIU, KWAN-YIN, LEUNG, SHUI-ON, YAU, MING-HON, CHEUNG, KA-WA BENNY
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creator SIU, KWAN-YIN
LEUNG, SHUI-ON
YAU, MING-HON
CHEUNG, KA-WA BENNY
description A stable pharmaceutical formulation of a therapeutically active anti-CD22 antibody, Suciraslimab (or SM03), for injection. In particular, the formulations comprising, in addition to a suitable amount of the anti-CD22 antibody.The formulations comprise additionally at least one buffering agent, such as a phosphate buffer and a nonionic surfactant. Methods for preparing such stable formulation and their uses thereof are also provided. L'invention concerne une formulation pharmaceutique stable d'un anticorps anti-CD22 thérapeutiquement actif, le suciraslimab (ou SM03), pour injection. En particulier, l'invention concerne les formulations comprenant en outre une quantité appropriée de l'anticorps anti-CD22. Les formulations comprennent en outre au moins un agent tampon, tel qu'un tampon phosphate, et un tensioactif non ionique. L'invention concerne également des procédés de préparation d'une telle formulation stable et des utilisations associées.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title AQUEOUS FORMULATIONS OF AN ANTI-CD22 ANTIBODY AND USES THEREOF
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