SOLID FORMS OF 2-[(4-{6-[(4-CYANO-2-FLUOROBENZYL)OXY]PYRIDIN-2-YL}PIPERIDIN-1-YL)METHYL]-1-[(2S)-OXETAN-2-YLMETHYL]-1H-BENZIMIDAZOLE-6-CARBOXYLIC ACID, 1,3-DIHYDROXY-2-(HYDROXYMETHYL)PROPAN-2-AMINE SALT

The invention provides solid forms of 2-[(4-{6-[(4-Cyano-2- fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S) -oxetan-2-ylmethyl]-1lH-benzimidazole-6-carboxylic acid, 1,3- dihydroxy-2-(hydroxymethyl)propan-2-amine salt for example, Form 1 or Form 2; as well as pharmaceutical compositions,...

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Bibliographische Detailangaben
Hauptverfasser:	GRIFFITH, DAVID ANDREW, JIAO, WENHUA, TAYLOR, LISA JANE, BAGLEY, SCOTT W, CLARK, WESLEY DEWITT, SAMAS, BRIAN MATTHEW
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention provides solid forms of 2-[(4-{6-[(4-Cyano-2- fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2S) -oxetan-2-ylmethyl]-1lH-benzimidazole-6-carboxylic acid, 1,3- dihydroxy-2-(hydroxymethyl)propan-2-amine salt for example, Form 1 or Form 2; as well as pharmaceutical compositions, and the uses thereof in treating diseases, conditions or disorders modulated by GLP-1 R in a mammal, such as a human. Formula (I) L'invention concerne des formes solides de sel de 1,3-dihydroxy-2-(hydroxyméthyl)propan-2-amine d'acide 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}pipéridin-1-yl)méthyl]-1-[(2S)-oxétan-2-ylméthyl]-1H-benzimidazole-6-carboxylique, par exemple, la forme 1 ou la forme 2; ainsi que des compositions pharmaceutiques et leurs utilisations dans le traitement de maladies, de pathologies ou de troubles modulés par GLP-1R chez un mammifère, tel qu'un être humain. Formule (I)