SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS
This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degenerat...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TEGLEY, CHRISTOPHER MICHAEL REYNOLDS, CHARLES HOWARD BROWN, SEAN POMEROY ZHU, LIUSHENG TASKER, ANDREW STEWART GRICE, CHERYL A KOLLURI, RAO |
| description | This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degeneration. In particular embodiments, the compounds inhibit axonal degeneration, including axonal degeneration that results from reduction or depletion of NAD+ (e.g., inhibition of SARM1 NADase).
La présente invention concerne des dérivés de pyridine, des compositions de ceux-ci, et des procédés associés, utiles pour l'inhibition de l'activité de SARM1 et/ou pour le traitement ou la prévention de troubles neurologiques. L'activation de SARM1 peut provoquer une diminution rapide des taux de NAD+ dans des axons endommagés qui subissent alors une dégénération. Dans des modes de réalisation spécifiques, les composés inhibent la génération axonale, y compris la dégénération axonale qui résulte de la diminution ou de la déplétion de NAD+ (par ex., l'inhibition de SARM1 NADase). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA3226869A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA3226869A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA3226869A13</originalsourceid><addsrcrecordid>eNrjZDAJDnUKDvEMCQ1xdVEIiAzydPH0c1VwcQ3yDHMM8QxzDVZwDFYIdgzyNVTw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6OxkZGZhZmlo6GxkQoAQCmxCdG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS</title><source>esp@cenet</source><creator>TEGLEY, CHRISTOPHER MICHAEL ; REYNOLDS, CHARLES HOWARD ; BROWN, SEAN POMEROY ; ZHU, LIUSHENG ; TASKER, ANDREW STEWART ; GRICE, CHERYL A ; KOLLURI, RAO</creator><creatorcontrib>TEGLEY, CHRISTOPHER MICHAEL ; REYNOLDS, CHARLES HOWARD ; BROWN, SEAN POMEROY ; ZHU, LIUSHENG ; TASKER, ANDREW STEWART ; GRICE, CHERYL A ; KOLLURI, RAO</creatorcontrib><description>This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degeneration. In particular embodiments, the compounds inhibit axonal degeneration, including axonal degeneration that results from reduction or depletion of NAD+ (e.g., inhibition of SARM1 NADase).
La présente invention concerne des dérivés de pyridine, des compositions de ceux-ci, et des procédés associés, utiles pour l'inhibition de l'activité de SARM1 et/ou pour le traitement ou la prévention de troubles neurologiques. L'activation de SARM1 peut provoquer une diminution rapide des taux de NAD+ dans des axons endommagés qui subissent alors une dégénération. Dans des modes de réalisation spécifiques, les composés inhibent la génération axonale, y compris la dégénération axonale qui résulte de la diminution ou de la déplétion de NAD+ (par ex., l'inhibition de SARM1 NADase).</description><language>eng ; fre</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; FISHING ; FORESTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; ORGANIC CHEMISTRY ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; TRAPPING</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230202&DB=EPODOC&CC=CA&NR=3226869A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230202&DB=EPODOC&CC=CA&NR=3226869A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TEGLEY, CHRISTOPHER MICHAEL</creatorcontrib><creatorcontrib>REYNOLDS, CHARLES HOWARD</creatorcontrib><creatorcontrib>BROWN, SEAN POMEROY</creatorcontrib><creatorcontrib>ZHU, LIUSHENG</creatorcontrib><creatorcontrib>TASKER, ANDREW STEWART</creatorcontrib><creatorcontrib>GRICE, CHERYL A</creatorcontrib><creatorcontrib>KOLLURI, RAO</creatorcontrib><title>SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS</title><description>This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degeneration. In particular embodiments, the compounds inhibit axonal degeneration, including axonal degeneration that results from reduction or depletion of NAD+ (e.g., inhibition of SARM1 NADase).
La présente invention concerne des dérivés de pyridine, des compositions de ceux-ci, et des procédés associés, utiles pour l'inhibition de l'activité de SARM1 et/ou pour le traitement ou la prévention de troubles neurologiques. L'activation de SARM1 peut provoquer une diminution rapide des taux de NAD+ dans des axons endommagés qui subissent alors une dégénération. Dans des modes de réalisation spécifiques, les composés inhibent la génération axonale, y compris la dégénération axonale qui résulte de la diminution ou de la déplétion de NAD+ (par ex., l'inhibition de SARM1 NADase).</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJDnUKDvEMCQ1xdVEIiAzydPH0c1VwcQ3yDHMM8QxzDVZwDFYIdgzyNVTw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6OxkZGZhZmlo6GxkQoAQCmxCdG</recordid><startdate>20230202</startdate><enddate>20230202</enddate><creator>TEGLEY, CHRISTOPHER MICHAEL</creator><creator>REYNOLDS, CHARLES HOWARD</creator><creator>BROWN, SEAN POMEROY</creator><creator>ZHU, LIUSHENG</creator><creator>TASKER, ANDREW STEWART</creator><creator>GRICE, CHERYL A</creator><creator>KOLLURI, RAO</creator><scope>EVB</scope></search><sort><creationdate>20230202</creationdate><title>SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS</title><author>TEGLEY, CHRISTOPHER MICHAEL ; REYNOLDS, CHARLES HOWARD ; BROWN, SEAN POMEROY ; ZHU, LIUSHENG ; TASKER, ANDREW STEWART ; GRICE, CHERYL A ; KOLLURI, RAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3226869A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>TRAPPING</topic><toplevel>online_resources</toplevel><creatorcontrib>TEGLEY, CHRISTOPHER MICHAEL</creatorcontrib><creatorcontrib>REYNOLDS, CHARLES HOWARD</creatorcontrib><creatorcontrib>BROWN, SEAN POMEROY</creatorcontrib><creatorcontrib>ZHU, LIUSHENG</creatorcontrib><creatorcontrib>TASKER, ANDREW STEWART</creatorcontrib><creatorcontrib>GRICE, CHERYL A</creatorcontrib><creatorcontrib>KOLLURI, RAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TEGLEY, CHRISTOPHER MICHAEL</au><au>REYNOLDS, CHARLES HOWARD</au><au>BROWN, SEAN POMEROY</au><au>ZHU, LIUSHENG</au><au>TASKER, ANDREW STEWART</au><au>GRICE, CHERYL A</au><au>KOLLURI, RAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS</title><date>2023-02-02</date><risdate>2023</risdate><abstract>This disclosure is drawn to pyridine derivatives, compositions thereof: and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders. SARM1 activation can cause a rapid reduction in NAD+ levels in injured axons, which then undergo degeneration. In particular embodiments, the compounds inhibit axonal degeneration, including axonal degeneration that results from reduction or depletion of NAD+ (e.g., inhibition of SARM1 NADase).
La présente invention concerne des dérivés de pyridine, des compositions de ceux-ci, et des procédés associés, utiles pour l'inhibition de l'activité de SARM1 et/ou pour le traitement ou la prévention de troubles neurologiques. L'activation de SARM1 peut provoquer une diminution rapide des taux de NAD+ dans des axons endommagés qui subissent alors une dégénération. Dans des modes de réalisation spécifiques, les composés inhibent la génération axonale, y compris la dégénération axonale qui résulte de la diminution ou de la déplétion de NAD+ (par ex., l'inhibition de SARM1 NADase).</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA3226869A1 |
| source | esp@cenet |
| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
| title | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A19%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TEGLEY,%20CHRISTOPHER%20MICHAEL&rft.date=2023-02-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA3226869A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |