SYNTHESIS OF A BIS-MESYLATE SALT OF 4-AMINO-N-(1 -((3-CHLORO-2- FLUOROPHENYL)AMINO)-6-METHYLISOQUINOLIN-5-YL)THIENO[3,2- D]PYRIMIDINE-7-CARBOXAMIDE AND INTERMEDIATES THERETO

A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylatio...

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Hauptverfasser:	ZHANG, HAIMING, ZHANG, JIE, MONDIERE, REGIS JEAN GEORGES, DALZIEL, MICHAEL EUAN, CARRERA, DIANE ELIZABETH, GE, YONGHUI, GOSSELIN, FRANCIS, ZELL, DANIEL, BIGLER, RAPHAEL, KOENIG, STEFAN G, NAKAGAWA, YUKI, MERCADO-MARIN, EDUARDO V, BACHMANN, STEPHAN, FINET, LAURE ELISABETH SIMONE, STUMPF, ANDREAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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