MULTI AGONISTS AND USE THEREOF
The present invention relates to the fields of medicine and biology, particularly relates to a triagonist polypeptide compound of general formula (I) or a salt or a solvate thereof, which compound has triple agonism activity on a glucagon-like peptide-1 receptor (GLP-1 R), a glucose-dependent insuli...
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| creator | DENG, HUIXING HE, XIUYI XIE, XIN HUANG, LIANG ZHOU, CUI LIU, XIAOXIAO CAO, CHUNLAI |
| description | The present invention relates to the fields of medicine and biology, particularly relates to a triagonist polypeptide compound of general formula (I) or a salt or a solvate thereof, which compound has triple agonism activity on a glucagon-like peptide-1 receptor (GLP-1 R), a glucose-dependent insulinotropic polypeptide receptor (GIP R) and a glucagon receptor (GCG R), and relates to the use thereof in the treatment of metabolic syndrome.
La présente invention concerne les domaines de la médecine et de la biologie et, en particulier, un composé polypeptidique triagoniste de formule générale (I) ou un sel ou un solvate de celui-ci, ledit composé présentant une triple activité agoniste sur un récepteur au peptide-1 de type glucagon (GLP-1R), un récepteur au polypeptide insulinotrope glucose-dépendant (GIP R) et un récepteur au glucagon (GCG R), et concerne l'utilisation de celui-ci dans le traitement du syndrome métabolique. |
| format | Patent |
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La présente invention concerne les domaines de la médecine et de la biologie et, en particulier, un composé polypeptidique triagoniste de formule générale (I) ou un sel ou un solvate de celui-ci, ledit composé présentant une triple activité agoniste sur un récepteur au peptide-1 de type glucagon (GLP-1R), un récepteur au polypeptide insulinotrope glucose-dépendant (GIP R) et un récepteur au glucagon (GCG R), et concerne l'utilisation de celui-ci dans le traitement du syndrome métabolique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221201&DB=EPODOC&CC=CA&NR=3219647A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221201&DB=EPODOC&CC=CA&NR=3219647A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DENG, HUIXING</creatorcontrib><creatorcontrib>HE, XIUYI</creatorcontrib><creatorcontrib>XIE, XIN</creatorcontrib><creatorcontrib>HUANG, LIANG</creatorcontrib><creatorcontrib>ZHOU, CUI</creatorcontrib><creatorcontrib>LIU, XIAOXIAO</creatorcontrib><creatorcontrib>CAO, CHUNLAI</creatorcontrib><title>MULTI AGONISTS AND USE THEREOF</title><description>The present invention relates to the fields of medicine and biology, particularly relates to a triagonist polypeptide compound of general formula (I) or a salt or a solvate thereof, which compound has triple agonism activity on a glucagon-like peptide-1 receptor (GLP-1 R), a glucose-dependent insulinotropic polypeptide receptor (GIP R) and a glucagon receptor (GCG R), and relates to the use thereof in the treatment of metabolic syndrome.
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MULTI AGONISTS AND USE THEREOF |
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