DEUTERATED ETORICOXIB, METHODS OF MANUFACTURE, AND USE THEREOF

Disclosed herein are compounds, such as compounds of Formulae (I), (II), and (III), and d3-etoricoxib, and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co- crystals, metabolites, and prodrugs thereof, and compositions, methods, uses, and kits thereof. The compounds disclosed he...

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1. Verfasser: SIPPY, BRADFORD C
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description Disclosed herein are compounds, such as compounds of Formulae (I), (II), and (III), and d3-etoricoxib, and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co- crystals, metabolites, and prodrugs thereof, and compositions, methods, uses, and kits thereof. The compounds disclosed herein are COX inhibitors and are therefore useful for the treatment and/or prevention of various conditions (e.g., inflammation, pain, or fever). La divulgation concerne des composés, tels que des composés de formules (I), (II), et (III) et du d3-étoricoxib, ainsi que des sels, des hydrates, des solvates, des polymorphes, des co-cristaux, des métabolites et des promédicaments pharmaceutiquement acceptables correspondant, de même que des compositions, des procédés, des utilisations et des kits correspondants. Les composés divulgués sont des inhibiteurs de COX et sont par conséquent utiles pour le traitement et/ou la prévention de divers états pathologiques (par exemple l'inflammation, la douleur ou la fièvre).
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The compounds disclosed herein are COX inhibitors and are therefore useful for the treatment and/or prevention of various conditions (e.g., inflammation, pain, or fever). La divulgation concerne des composés, tels que des composés de formules (I), (II), et (III) et du d3-étoricoxib, ainsi que des sels, des hydrates, des solvates, des polymorphes, des co-cristaux, des métabolites et des promédicaments pharmaceutiquement acceptables correspondant, de même que des compositions, des procédés, des utilisations et des kits correspondants. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DEUTERATED ETORICOXIB, METHODS OF MANUFACTURE, AND USE THEREOF
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