HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS
The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the inve...
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| creator | ZIHER, DINKO ACCETTA, ALESSANDRO RANCATI, FABIO BUTKOVIC, KRISTINA CUZZOLIN, ALBERTO ELENKOV, IVAYLO MESIC, MILAN RIZZI, ANDREA |
| description | The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.
La présente invention concerne un composé de formule générale (I) inhibant la famille JAK des protéines kinases à tyrosine non réceptrices (JAK1, JAK2, JAK3 et TYK2) ; des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles dans le traitement de maladies ou d'états associés à un dérèglement des kinases non réceptrices de la famille JAK ; en particulier pour le traitement de diverses maladies inflammatoires, notamment l'asthme, la BPCO et d'autres maladies respiratoires. |
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La présente invention concerne un composé de formule générale (I) inhibant la famille JAK des protéines kinases à tyrosine non réceptrices (JAK1, JAK2, JAK3 et TYK2) ; des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles dans le traitement de maladies ou d'états associés à un dérèglement des kinases non réceptrices de la famille JAK ; en particulier pour le traitement de diverses maladies inflammatoires, notamment l'asthme, la BPCO et d'autres maladies respiratoires.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220922&DB=EPODOC&CC=CA&NR=3211584A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220922&DB=EPODOC&CC=CA&NR=3211584A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZIHER, DINKO</creatorcontrib><creatorcontrib>ACCETTA, ALESSANDRO</creatorcontrib><creatorcontrib>RANCATI, FABIO</creatorcontrib><creatorcontrib>BUTKOVIC, KRISTINA</creatorcontrib><creatorcontrib>CUZZOLIN, ALBERTO</creatorcontrib><creatorcontrib>ELENKOV, IVAYLO</creatorcontrib><creatorcontrib>MESIC, MILAN</creatorcontrib><creatorcontrib>RIZZI, ANDREA</creatorcontrib><title>HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS</title><description>The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.
La présente invention concerne un composé de formule générale (I) inhibant la famille JAK des protéines kinases à tyrosine non réceptrices (JAK1, JAK2, JAK3 et TYK2) ; des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles dans le traitement de maladies ou d'états associés à un dérèglement des kinases non réceptrices de la famille JAK ; en particulier pour le traitement de diverses maladies inflammatoires, notamment l'asthme, la BPCO et d'autres maladies respiratoires.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD2cA1xDfJ3jnT28XRWcHEN8gxzDPEMcw1WcAxW8HL0Cw1W8Pb0cwx2VfD08_B08gzxDwrmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo7GRoaGphYmjobGRCgBAGbvJr8</recordid><startdate>20220922</startdate><enddate>20220922</enddate><creator>ZIHER, DINKO</creator><creator>ACCETTA, ALESSANDRO</creator><creator>RANCATI, FABIO</creator><creator>BUTKOVIC, KRISTINA</creator><creator>CUZZOLIN, ALBERTO</creator><creator>ELENKOV, IVAYLO</creator><creator>MESIC, MILAN</creator><creator>RIZZI, ANDREA</creator><scope>EVB</scope></search><sort><creationdate>20220922</creationdate><title>HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS</title><author>ZIHER, DINKO ; ACCETTA, ALESSANDRO ; RANCATI, FABIO ; BUTKOVIC, KRISTINA ; CUZZOLIN, ALBERTO ; ELENKOV, IVAYLO ; MESIC, MILAN ; RIZZI, ANDREA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3211584A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZIHER, DINKO</creatorcontrib><creatorcontrib>ACCETTA, ALESSANDRO</creatorcontrib><creatorcontrib>RANCATI, FABIO</creatorcontrib><creatorcontrib>BUTKOVIC, KRISTINA</creatorcontrib><creatorcontrib>CUZZOLIN, ALBERTO</creatorcontrib><creatorcontrib>ELENKOV, IVAYLO</creatorcontrib><creatorcontrib>MESIC, MILAN</creatorcontrib><creatorcontrib>RIZZI, ANDREA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZIHER, DINKO</au><au>ACCETTA, ALESSANDRO</au><au>RANCATI, FABIO</au><au>BUTKOVIC, KRISTINA</au><au>CUZZOLIN, ALBERTO</au><au>ELENKOV, IVAYLO</au><au>MESIC, MILAN</au><au>RIZZI, ANDREA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS</title><date>2022-09-22</date><risdate>2022</risdate><abstract>The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.
La présente invention concerne un composé de formule générale (I) inhibant la famille JAK des protéines kinases à tyrosine non réceptrices (JAK1, JAK2, JAK3 et TYK2) ; des procédés de préparation de tels composés, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles dans le traitement de maladies ou d'états associés à un dérèglement des kinases non réceptrices de la famille JAK ; en particulier pour le traitement de diverses maladies inflammatoires, notamment l'asthme, la BPCO et d'autres maladies respiratoires.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS |
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