METHOD AND SYSTEM FOR PREDICTING PROPERTIES OF AMORPHOUS SOLID DISPERSIONS USING MACHINE LEARNING
Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The meth...
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| creator | DURIG, THOMAS JACOBSON, SOLOMON HOWARD BI, YUNXIA |
| description | Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.
La présente invention concerne un procédé à base d'intelligence artificielle et un système, qui utilise à la fois des données de résultats expérimentaux et une simulation moléculaire pour prédire les propriétés de dispersions solides amorphes telles que la température de transition vitreuse, le profil de dissolution et/ou la stabilité physique. Le procédé et le système selon la présente invention permettent une conception rationnelle de dispersions solides amorphes pour des médicaments faiblement solubles dans l'eau et réduisent significativement le temps et les ressources requises pour le développement de formulations de dispersions solides amorphes. |
| format | Patent |
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La présente invention concerne un procédé à base d'intelligence artificielle et un système, qui utilise à la fois des données de résultats expérimentaux et une simulation moléculaire pour prédire les propriétés de dispersions solides amorphes telles que la température de transition vitreuse, le profil de dissolution et/ou la stabilité physique. Le procédé et le système selon la présente invention permettent une conception rationnelle de dispersions solides amorphes pour des médicaments faiblement solubles dans l'eau et réduisent significativement le temps et les ressources requises pour le développement de formulations de dispersions solides amorphes.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220505&DB=EPODOC&CC=CA&NR=3196452A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220505&DB=EPODOC&CC=CA&NR=3196452A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DURIG, THOMAS</creatorcontrib><creatorcontrib>JACOBSON, SOLOMON HOWARD</creatorcontrib><creatorcontrib>BI, YUNXIA</creatorcontrib><title>METHOD AND SYSTEM FOR PREDICTING PROPERTIES OF AMORPHOUS SOLID DISPERSIONS USING MACHINE LEARNING</title><description>Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.
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La présente invention concerne un procédé à base d'intelligence artificielle et un système, qui utilise à la fois des données de résultats expérimentaux et une simulation moléculaire pour prédire les propriétés de dispersions solides amorphes telles que la température de transition vitreuse, le profil de dissolution et/ou la stabilité physique. Le procédé et le système selon la présente invention permettent une conception rationnelle de dispersions solides amorphes pour des médicaments faiblement solubles dans l'eau et réduisent significativement le temps et les ressources requises pour le développement de formulations de dispersions solides amorphes.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | METHOD AND SYSTEM FOR PREDICTING PROPERTIES OF AMORPHOUS SOLID DISPERSIONS USING MACHINE LEARNING |
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