LZK-TARGETING DEGRADERS AND METHODS OF USE
Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases o...
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| creator | SABBASANI, VENKATAREDDY LINDBERG, ERIC HITKO, CAROLYN W NYSWANER, KATHERINE M FUNK, AMY L BERGMAN, KNICKOLE L SWENSON, ROLF E BROGNARD, JOHN F |
| description | Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression.
L'invention concerne des agents de dégradation ciblés sur une kinase portant une fermeture à glissière à leucine (LZK). Les composés ont une formule générale Q-L-Z, Q étant une fraction de liaison LZK, L étant un lieur, et Z étant une fraction de liaison à la ligase E3. Les composés inhibent l'activité LZK et/ou dégradent la LZK. Les composés peuvent être utilisés pour traiter des maladies ou des affections caractérisées au moins en partie par une surexpression de LZK. |
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L'invention concerne des agents de dégradation ciblés sur une kinase portant une fermeture à glissière à leucine (LZK). Les composés ont une formule générale Q-L-Z, Q étant une fraction de liaison LZK, L étant un lieur, et Z étant une fraction de liaison à la ligase E3. Les composés inhibent l'activité LZK et/ou dégradent la LZK. Les composés peuvent être utilisés pour traiter des maladies ou des affections caractérisées au moins en partie par une surexpression de LZK.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220310&DB=EPODOC&CC=CA&NR=3193736A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220310&DB=EPODOC&CC=CA&NR=3193736A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SABBASANI, VENKATAREDDY</creatorcontrib><creatorcontrib>LINDBERG, ERIC</creatorcontrib><creatorcontrib>HITKO, CAROLYN W</creatorcontrib><creatorcontrib>NYSWANER, KATHERINE M</creatorcontrib><creatorcontrib>FUNK, AMY L</creatorcontrib><creatorcontrib>BERGMAN, KNICKOLE L</creatorcontrib><creatorcontrib>SWENSON, ROLF E</creatorcontrib><creatorcontrib>BROGNARD, JOHN F</creatorcontrib><title>LZK-TARGETING DEGRADERS AND METHODS OF USE</title><description>Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression.
L'invention concerne des agents de dégradation ciblés sur une kinase portant une fermeture à glissière à leucine (LZK). Les composés ont une formule générale Q-L-Z, Q étant une fraction de liaison LZK, L étant un lieur, et Z étant une fraction de liaison à la ligase E3. Les composés inhibent l'activité LZK et/ou dégradent la LZK. Les composés peuvent être utilisés pour traiter des maladies ou des affections caractérisées au moins en partie par une surexpression de LZK.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDyifLWDXEMcncN8fRzV3BxdQ9ydHENClZw9HNR8HUN8fB3CVbwd1MIDXblYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxzo7GhpbG5sZmjobGRCgBAPY4I_Q</recordid><startdate>20220310</startdate><enddate>20220310</enddate><creator>SABBASANI, VENKATAREDDY</creator><creator>LINDBERG, ERIC</creator><creator>HITKO, CAROLYN W</creator><creator>NYSWANER, KATHERINE M</creator><creator>FUNK, AMY L</creator><creator>BERGMAN, KNICKOLE L</creator><creator>SWENSON, ROLF E</creator><creator>BROGNARD, JOHN F</creator><scope>EVB</scope></search><sort><creationdate>20220310</creationdate><title>LZK-TARGETING DEGRADERS AND METHODS OF USE</title><author>SABBASANI, VENKATAREDDY ; LINDBERG, ERIC ; HITKO, CAROLYN W ; NYSWANER, KATHERINE M ; FUNK, AMY L ; BERGMAN, KNICKOLE L ; SWENSON, ROLF E ; BROGNARD, JOHN F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3193736A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SABBASANI, VENKATAREDDY</creatorcontrib><creatorcontrib>LINDBERG, ERIC</creatorcontrib><creatorcontrib>HITKO, CAROLYN W</creatorcontrib><creatorcontrib>NYSWANER, KATHERINE M</creatorcontrib><creatorcontrib>FUNK, AMY L</creatorcontrib><creatorcontrib>BERGMAN, KNICKOLE L</creatorcontrib><creatorcontrib>SWENSON, ROLF E</creatorcontrib><creatorcontrib>BROGNARD, JOHN F</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SABBASANI, VENKATAREDDY</au><au>LINDBERG, ERIC</au><au>HITKO, CAROLYN W</au><au>NYSWANER, KATHERINE M</au><au>FUNK, AMY L</au><au>BERGMAN, KNICKOLE L</au><au>SWENSON, ROLF E</au><au>BROGNARD, JOHN F</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>LZK-TARGETING DEGRADERS AND METHODS OF USE</title><date>2022-03-10</date><risdate>2022</risdate><abstract>Leucine zipper-bearing kinase (LZK) targeted degraders are disclosed. The compounds have a general formula Q-L-Z where Q is an LZK binding moiety, L is a linker, and Z is an E3-ligase binding moiety. The compounds inhibit LZK activity and/or degrade LZK. The compounds may be used to treat diseases or conditions characterized at least in part by LZK overexpression.
L'invention concerne des agents de dégradation ciblés sur une kinase portant une fermeture à glissière à leucine (LZK). Les composés ont une formule générale Q-L-Z, Q étant une fraction de liaison LZK, L étant un lieur, et Z étant une fraction de liaison à la ligase E3. Les composés inhibent l'activité LZK et/ou dégradent la LZK. Les composés peuvent être utilisés pour traiter des maladies ou des affections caractérisées au moins en partie par une surexpression de LZK.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | LZK-TARGETING DEGRADERS AND METHODS OF USE |
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