SYSTEMS AND METHODS FOR DIFFERENTIATING HEMATOPOIETIC CELLS
Disclosed are media, methods, systems and kits for differentiating hematopoietic progenitor cells from a population of early mesoderm cells under conditions that exclude any combination of certain exogenously added agonists of growth factor signaling. The population of early mesoderm cells may be de...
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| creator | TABATABAEI-ZAVAREH, NOOSHIN LE FEVRE, TIM |
| description | Disclosed are media, methods, systems and kits for differentiating hematopoietic progenitor cells from a population of early mesoderm cells under conditions that exclude any combination of certain exogenously added agonists of growth factor signaling. The population of early mesoderm cells may be derived from pluripotent stem cells, and the hematopoietic progenitor cells differentiated under the disclosed conditions are multipotent. The culture conditions disclosure herein may form serum-free workflows and/or workflows free of stroma and/or feeder cells.
Des milieux, des procédés, des systèmes et des kits pour différencier des cellules progénitrices hématopoïétiques d'une population de cellules de mésoderme précoce dans des conditions qui excluent toute combinaison de certains agonistes, ajoutés de manière exogène, de la signalisation du facteur de croissance sont divulgués. La population de cellules de mésoderme précoce peut être dérivée de cellules souches pluripotentes et les cellules progénitrices hématopoïétiques différenciées dans les conditions divulguées sont multipotentes. Les conditions de culture de la présente divulgation peuvent former des flux de travail exempts de sérum et/ou des flux de travail exempts de stroma et/ou de cellules nourricières. |
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Des milieux, des procédés, des systèmes et des kits pour différencier des cellules progénitrices hématopoïétiques d'une population de cellules de mésoderme précoce dans des conditions qui excluent toute combinaison de certains agonistes, ajoutés de manière exogène, de la signalisation du facteur de croissance sont divulgués. La population de cellules de mésoderme précoce peut être dérivée de cellules souches pluripotentes et les cellules progénitrices hématopoïétiques différenciées dans les conditions divulguées sont multipotentes. Les conditions de culture de la présente divulgation peuvent former des flux de travail exempts de sérum et/ou des flux de travail exempts de stroma et/ou de cellules nourricières.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220203&DB=EPODOC&CC=CA&NR=3174380A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220203&DB=EPODOC&CC=CA&NR=3174380A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TABATABAEI-ZAVAREH, NOOSHIN</creatorcontrib><creatorcontrib>LE FEVRE, TIM</creatorcontrib><title>SYSTEMS AND METHODS FOR DIFFERENTIATING HEMATOPOIETIC CELLS</title><description>Disclosed are media, methods, systems and kits for differentiating hematopoietic progenitor cells from a population of early mesoderm cells under conditions that exclude any combination of certain exogenously added agonists of growth factor signaling. The population of early mesoderm cells may be derived from pluripotent stem cells, and the hematopoietic progenitor cells differentiated under the disclosed conditions are multipotent. The culture conditions disclosure herein may form serum-free workflows and/or workflows free of stroma and/or feeder cells.
Des milieux, des procédés, des systèmes et des kits pour différencier des cellules progénitrices hématopoïétiques d'une population de cellules de mésoderme précoce dans des conditions qui excluent toute combinaison de certains agonistes, ajoutés de manière exogène, de la signalisation du facteur de croissance sont divulgués. La population de cellules de mésoderme précoce peut être dérivée de cellules souches pluripotentes et les cellules progénitrices hématopoïétiques différenciées dans les conditions divulguées sont multipotentes. Les conditions de culture de la présente divulgation peuvent former des flux de travail exempts de sérum et/ou des flux de travail exempts de stroma et/ou de cellules nourricières.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAOjgwOcfUNVnD0c1HwdQ3x8HcJVnDzD1Jw8XRzcw1y9QvxdAzx9HNX8HD1dQzxD_D3dA3xdFZwdvXxCeZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjsaG5ibGFgaOhsZEKAEAoSgo8w</recordid><startdate>20220203</startdate><enddate>20220203</enddate><creator>TABATABAEI-ZAVAREH, NOOSHIN</creator><creator>LE FEVRE, TIM</creator><scope>EVB</scope></search><sort><creationdate>20220203</creationdate><title>SYSTEMS AND METHODS FOR DIFFERENTIATING HEMATOPOIETIC CELLS</title><author>TABATABAEI-ZAVAREH, NOOSHIN ; LE FEVRE, TIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3174380A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TABATABAEI-ZAVAREH, NOOSHIN</creatorcontrib><creatorcontrib>LE FEVRE, TIM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TABATABAEI-ZAVAREH, NOOSHIN</au><au>LE FEVRE, TIM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYSTEMS AND METHODS FOR DIFFERENTIATING HEMATOPOIETIC CELLS</title><date>2022-02-03</date><risdate>2022</risdate><abstract>Disclosed are media, methods, systems and kits for differentiating hematopoietic progenitor cells from a population of early mesoderm cells under conditions that exclude any combination of certain exogenously added agonists of growth factor signaling. The population of early mesoderm cells may be derived from pluripotent stem cells, and the hematopoietic progenitor cells differentiated under the disclosed conditions are multipotent. The culture conditions disclosure herein may form serum-free workflows and/or workflows free of stroma and/or feeder cells.
Des milieux, des procédés, des systèmes et des kits pour différencier des cellules progénitrices hématopoïétiques d'une population de cellules de mésoderme précoce dans des conditions qui excluent toute combinaison de certains agonistes, ajoutés de manière exogène, de la signalisation du facteur de croissance sont divulgués. La population de cellules de mésoderme précoce peut être dérivée de cellules souches pluripotentes et les cellules progénitrices hématopoïétiques différenciées dans les conditions divulguées sont multipotentes. Les conditions de culture de la présente divulgation peuvent former des flux de travail exempts de sérum et/ou des flux de travail exempts de stroma et/ou de cellules nourricières.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | SYSTEMS AND METHODS FOR DIFFERENTIATING HEMATOPOIETIC CELLS |
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