METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS
This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Us...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NAIK, KUMAR RAM PRABAKARAN, KAMALAKANNAN SANTOSHKUMAR, SHANKAR DANGE AMIT, DATTATRAY KARCHE KAMBOJ, RAJENDER KUMAR PADIYA, KAMLESH JYOTINDRA RAJENDRA, GANPATI POWAR SITARAM RAMBHAU, BARVE RAJESH, BHAVANI SHANKAR SACHIN, SUBHASH INGAWALE |
| description | This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
La présente invention concerne un procédé et un processus économiques et évolutifs pour synthétiser l'agent de modulation du récepteur sensible au calcium (CaSR), à savoir l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque, ses intermédiaires et leurs sels pharmaceutiquement acceptables. L'invention concerne également des utilisations desdits intermédiaires pour la synthèse de composés qui peuvent être des intermédiaires pour la synthèse de l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA3166512A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA3166512A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA3166512A13</originalsourceid><addsrcrecordid>eNrjZHDxdQ3x8HcJ1lEICPJ3dg0Odg1WcPRzUfD0C3EN8nV18XQMAYq4-QcB5V0DHIM8_dwVnD2C_H0d_RSc_X0D_EP9XIJ5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakm8s6OxoZmZqaGRo6ExEUoAE0graA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS</title><source>esp@cenet</source><creator>NAIK, KUMAR RAM ; PRABAKARAN, KAMALAKANNAN ; SANTOSHKUMAR, SHANKAR DANGE ; AMIT, DATTATRAY KARCHE ; KAMBOJ, RAJENDER KUMAR ; PADIYA, KAMLESH JYOTINDRA ; RAJENDRA, GANPATI POWAR ; SITARAM RAMBHAU, BARVE ; RAJESH, BHAVANI SHANKAR ; SACHIN, SUBHASH INGAWALE</creator><creatorcontrib>NAIK, KUMAR RAM ; PRABAKARAN, KAMALAKANNAN ; SANTOSHKUMAR, SHANKAR DANGE ; AMIT, DATTATRAY KARCHE ; KAMBOJ, RAJENDER KUMAR ; PADIYA, KAMLESH JYOTINDRA ; RAJENDRA, GANPATI POWAR ; SITARAM RAMBHAU, BARVE ; RAJESH, BHAVANI SHANKAR ; SACHIN, SUBHASH INGAWALE</creatorcontrib><description>This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
La présente invention concerne un procédé et un processus économiques et évolutifs pour synthétiser l'agent de modulation du récepteur sensible au calcium (CaSR), à savoir l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque, ses intermédiaires et leurs sels pharmaceutiquement acceptables. L'invention concerne également des utilisations desdits intermédiaires pour la synthèse de composés qui peuvent être des intermédiaires pour la synthèse de l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210722&DB=EPODOC&CC=CA&NR=3166512A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210722&DB=EPODOC&CC=CA&NR=3166512A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAIK, KUMAR RAM</creatorcontrib><creatorcontrib>PRABAKARAN, KAMALAKANNAN</creatorcontrib><creatorcontrib>SANTOSHKUMAR, SHANKAR DANGE</creatorcontrib><creatorcontrib>AMIT, DATTATRAY KARCHE</creatorcontrib><creatorcontrib>KAMBOJ, RAJENDER KUMAR</creatorcontrib><creatorcontrib>PADIYA, KAMLESH JYOTINDRA</creatorcontrib><creatorcontrib>RAJENDRA, GANPATI POWAR</creatorcontrib><creatorcontrib>SITARAM RAMBHAU, BARVE</creatorcontrib><creatorcontrib>RAJESH, BHAVANI SHANKAR</creatorcontrib><creatorcontrib>SACHIN, SUBHASH INGAWALE</creatorcontrib><title>METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS</title><description>This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
La présente invention concerne un procédé et un processus économiques et évolutifs pour synthétiser l'agent de modulation du récepteur sensible au calcium (CaSR), à savoir l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque, ses intermédiaires et leurs sels pharmaceutiquement acceptables. L'invention concerne également des utilisations desdits intermédiaires pour la synthèse de composés qui peuvent être des intermédiaires pour la synthèse de l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDxdQ3x8HcJ1lEICPJ3dg0Odg1WcPRzUfD0C3EN8nV18XQMAYq4-QcB5V0DHIM8_dwVnD2C_H0d_RSc_X0D_EP9XIJ5GFjTEnOKU3mhNDeDgptriLOHbmpBfnxqcUFicmpeakm8s6OxoZmZqaGRo6ExEUoAE0graA</recordid><startdate>20210722</startdate><enddate>20210722</enddate><creator>NAIK, KUMAR RAM</creator><creator>PRABAKARAN, KAMALAKANNAN</creator><creator>SANTOSHKUMAR, SHANKAR DANGE</creator><creator>AMIT, DATTATRAY KARCHE</creator><creator>KAMBOJ, RAJENDER KUMAR</creator><creator>PADIYA, KAMLESH JYOTINDRA</creator><creator>RAJENDRA, GANPATI POWAR</creator><creator>SITARAM RAMBHAU, BARVE</creator><creator>RAJESH, BHAVANI SHANKAR</creator><creator>SACHIN, SUBHASH INGAWALE</creator><scope>EVB</scope></search><sort><creationdate>20210722</creationdate><title>METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS</title><author>NAIK, KUMAR RAM ; PRABAKARAN, KAMALAKANNAN ; SANTOSHKUMAR, SHANKAR DANGE ; AMIT, DATTATRAY KARCHE ; KAMBOJ, RAJENDER KUMAR ; PADIYA, KAMLESH JYOTINDRA ; RAJENDRA, GANPATI POWAR ; SITARAM RAMBHAU, BARVE ; RAJESH, BHAVANI SHANKAR ; SACHIN, SUBHASH INGAWALE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3166512A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>NAIK, KUMAR RAM</creatorcontrib><creatorcontrib>PRABAKARAN, KAMALAKANNAN</creatorcontrib><creatorcontrib>SANTOSHKUMAR, SHANKAR DANGE</creatorcontrib><creatorcontrib>AMIT, DATTATRAY KARCHE</creatorcontrib><creatorcontrib>KAMBOJ, RAJENDER KUMAR</creatorcontrib><creatorcontrib>PADIYA, KAMLESH JYOTINDRA</creatorcontrib><creatorcontrib>RAJENDRA, GANPATI POWAR</creatorcontrib><creatorcontrib>SITARAM RAMBHAU, BARVE</creatorcontrib><creatorcontrib>RAJESH, BHAVANI SHANKAR</creatorcontrib><creatorcontrib>SACHIN, SUBHASH INGAWALE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAIK, KUMAR RAM</au><au>PRABAKARAN, KAMALAKANNAN</au><au>SANTOSHKUMAR, SHANKAR DANGE</au><au>AMIT, DATTATRAY KARCHE</au><au>KAMBOJ, RAJENDER KUMAR</au><au>PADIYA, KAMLESH JYOTINDRA</au><au>RAJENDRA, GANPATI POWAR</au><au>SITARAM RAMBHAU, BARVE</au><au>RAJESH, BHAVANI SHANKAR</au><au>SACHIN, SUBHASH INGAWALE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS</title><date>2021-07-22</date><risdate>2021</risdate><abstract>This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-(((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.
La présente invention concerne un procédé et un processus économiques et évolutifs pour synthétiser l'agent de modulation du récepteur sensible au calcium (CaSR), à savoir l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque, ses intermédiaires et leurs sels pharmaceutiquement acceptables. L'invention concerne également des utilisations desdits intermédiaires pour la synthèse de composés qui peuvent être des intermédiaires pour la synthèse de l'acide 2-méthyl-5-((2R,4S)-2-(((R)-1-(naphtalén-1-yl)éthyl)amino)méthyl)chroman-4-yl)benzoïque.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA3166512A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | METHODS, PROCESSES AND INTERMEDIATES FOR PREPARING CHROMAN COMPOUNDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T03%3A55%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NAIK,%20KUMAR%20RAM&rft.date=2021-07-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA3166512A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |