PHARMACEUTICAL COMPOSITION CONTAINING DOUBLE-STRANDED RIBONUCLEIC ACID INHIBITING EXPRESSION OF COMPLEMENT C5

Disclosed is a pharmaceutical composition containing a lipid complex, wherein the lipid complex includes a double-stranded ribonucleic acid having a sense chain comprising a nucleotide sequence represented by SEQ ID NO: 145, and an antisense chain comprising a nucleotide sequence represented by SEQ...

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Bibliographische Detailangaben
Hauptverfasser:	SUZUKI, YUTA, TAKEMOTO, SEIJI, ARASE, SHUNTARO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a pharmaceutical composition containing a lipid complex, wherein the lipid complex includes a double-stranded ribonucleic acid having a sense chain comprising a nucleotide sequence represented by SEQ ID NO: 145, and an antisense chain comprising a nucleotide sequence represented by SEQ ID NO: 146, and the pH of a lipid complex solution is 5.0 or less or 7.5 or more. L'invention concerne une composition pharmaceutique contenant un complexe lipidique, le complexe lipidique incluant un acide ribonucléique double brin ayant une chaîne sens comprenant une séquence nucléotidique représentée par SEQ ID NO : 145 et une chaîne antisens comprenant une séquence nucléotidique représentée par SEQ ID NO : 146, et le pH d'une solution de complexe lipidique étant de 5,0 ou moins ou de 7,5 ou plus.