ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF
Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FRa antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modif...
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| creator | CHUI, DANNY WICKMAN, GRANT RAYMOND SPRETER VON KREUDENSTEIN, THOMAS PATTON, DANIEL T PRATAP, HARSH CHAN, PETER WING YIU HALVORSEN, ELIZABETH ZWIERZCHOWSKI, PATRICIA MILLS, DAVID M CLAVETTE, BRANDON VON ROSSUM, ANNA FREIBURGER, LEE VOLKERS, GESA UROSEV, DUNJA DUAN, ZHUANG JANCOWSKI, SYLWIA KANG, SUKHBIR SINGH |
| description | Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FRa antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.
L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène anti-récepteur a de folate (FRa), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène FRa étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice. Les constructions d'anticorps sont utilisées dans le traitement d'un sujet atteint d'un cancer. |
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L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène anti-récepteur a de folate (FRa), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène FRa étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice. Les constructions d'anticorps sont utilisées dans le traitement d'un sujet atteint d'un cancer.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211021&DB=EPODOC&CC=CA&NR=3146977A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211021&DB=EPODOC&CC=CA&NR=3146977A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHUI, DANNY</creatorcontrib><creatorcontrib>WICKMAN, GRANT RAYMOND</creatorcontrib><creatorcontrib>SPRETER VON KREUDENSTEIN, THOMAS</creatorcontrib><creatorcontrib>PATTON, DANIEL T</creatorcontrib><creatorcontrib>PRATAP, HARSH</creatorcontrib><creatorcontrib>CHAN, PETER WING YIU</creatorcontrib><creatorcontrib>HALVORSEN, ELIZABETH</creatorcontrib><creatorcontrib>ZWIERZCHOWSKI, PATRICIA</creatorcontrib><creatorcontrib>MILLS, DAVID M</creatorcontrib><creatorcontrib>CLAVETTE, BRANDON</creatorcontrib><creatorcontrib>VON ROSSUM, ANNA</creatorcontrib><creatorcontrib>FREIBURGER, LEE</creatorcontrib><creatorcontrib>VOLKERS, GESA</creatorcontrib><creatorcontrib>UROSEV, DUNJA</creatorcontrib><creatorcontrib>DUAN, ZHUANG</creatorcontrib><creatorcontrib>JANCOWSKI, SYLWIA</creatorcontrib><creatorcontrib>KANG, SUKHBIR SINGH</creatorcontrib><title>ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF</title><description>Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FRa antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.
L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène anti-récepteur a de folate (FRa), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène FRa étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice. Les constructions d'anticorps sont utilisées dans le traitement d'un sujet atteint d'un cancer.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBx9AvxdPJ3iVRw9vcLDgkKdQ4JVnDy9HPx9HNXMNE1dHJScPRzUXDz93EMcVUIcnV2DQjxD1Jw9AnwcATLhAa7BiuEeLgGufq78TCwpiXmFKfyQmluBgU31xBnD93Ugvz41OKCxOTUvNSSeGdHY0MTM0tzc0dDYyKUAAAm1iz-</recordid><startdate>20211021</startdate><enddate>20211021</enddate><creator>CHUI, DANNY</creator><creator>WICKMAN, GRANT RAYMOND</creator><creator>SPRETER VON KREUDENSTEIN, THOMAS</creator><creator>PATTON, DANIEL T</creator><creator>PRATAP, HARSH</creator><creator>CHAN, PETER WING YIU</creator><creator>HALVORSEN, ELIZABETH</creator><creator>ZWIERZCHOWSKI, PATRICIA</creator><creator>MILLS, DAVID M</creator><creator>CLAVETTE, BRANDON</creator><creator>VON ROSSUM, ANNA</creator><creator>FREIBURGER, LEE</creator><creator>VOLKERS, GESA</creator><creator>UROSEV, DUNJA</creator><creator>DUAN, ZHUANG</creator><creator>JANCOWSKI, SYLWIA</creator><creator>KANG, SUKHBIR SINGH</creator><scope>EVB</scope></search><sort><creationdate>20211021</creationdate><title>ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF</title><author>CHUI, DANNY ; WICKMAN, GRANT RAYMOND ; SPRETER VON KREUDENSTEIN, THOMAS ; PATTON, DANIEL T ; PRATAP, HARSH ; CHAN, PETER WING YIU ; HALVORSEN, ELIZABETH ; ZWIERZCHOWSKI, PATRICIA ; MILLS, DAVID M ; CLAVETTE, BRANDON ; VON ROSSUM, ANNA ; FREIBURGER, LEE ; VOLKERS, GESA ; UROSEV, DUNJA ; DUAN, ZHUANG ; JANCOWSKI, SYLWIA ; KANG, SUKHBIR SINGH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3146977A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHUI, DANNY</creatorcontrib><creatorcontrib>WICKMAN, GRANT RAYMOND</creatorcontrib><creatorcontrib>SPRETER VON KREUDENSTEIN, THOMAS</creatorcontrib><creatorcontrib>PATTON, DANIEL T</creatorcontrib><creatorcontrib>PRATAP, HARSH</creatorcontrib><creatorcontrib>CHAN, PETER WING YIU</creatorcontrib><creatorcontrib>HALVORSEN, ELIZABETH</creatorcontrib><creatorcontrib>ZWIERZCHOWSKI, PATRICIA</creatorcontrib><creatorcontrib>MILLS, DAVID M</creatorcontrib><creatorcontrib>CLAVETTE, BRANDON</creatorcontrib><creatorcontrib>VON ROSSUM, ANNA</creatorcontrib><creatorcontrib>FREIBURGER, LEE</creatorcontrib><creatorcontrib>VOLKERS, GESA</creatorcontrib><creatorcontrib>UROSEV, DUNJA</creatorcontrib><creatorcontrib>DUAN, ZHUANG</creatorcontrib><creatorcontrib>JANCOWSKI, SYLWIA</creatorcontrib><creatorcontrib>KANG, SUKHBIR SINGH</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHUI, DANNY</au><au>WICKMAN, GRANT RAYMOND</au><au>SPRETER VON KREUDENSTEIN, THOMAS</au><au>PATTON, DANIEL T</au><au>PRATAP, HARSH</au><au>CHAN, PETER WING YIU</au><au>HALVORSEN, ELIZABETH</au><au>ZWIERZCHOWSKI, PATRICIA</au><au>MILLS, DAVID M</au><au>CLAVETTE, BRANDON</au><au>VON ROSSUM, ANNA</au><au>FREIBURGER, LEE</au><au>VOLKERS, GESA</au><au>UROSEV, DUNJA</au><au>DUAN, ZHUANG</au><au>JANCOWSKI, SYLWIA</au><au>KANG, SUKHBIR SINGH</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF</title><date>2021-10-21</date><risdate>2021</risdate><abstract>Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FRa antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.
L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène anti-récepteur a de folate (FRa), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène FRa étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice. Les constructions d'anticorps sont utilisées dans le traitement d'un sujet atteint d'un cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF |
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