PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE

PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE

The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention f...

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Hauptverfasser: FRANK, SCOTT ALAN, VAID, RADHE KRISHAN, ROTHHAAR, ROGER RYAN, KERR, MARK STEVEN, ABURUB, AKTHAM, COATES, DAVID ANDREW
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator FRANK, SCOTT ALAN
VAID, RADHE KRISHAN
ROTHHAAR, ROGER RYAN
KERR, MARK STEVEN
ABURUB, AKTHAM
COATES, DAVID ANDREW
description The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery. Les modes de réalisation de la présente invention concernent des procédés et un intermédiaire de préparation à grande échelle d'hémisuccinate de 2,4,6-trifluoro-N-[6-(1-méthylpipéridine-4-carbonyl)-2-pyridyl]benzamide, et des formulations et formes de produits fabriquées par ces procédés. Les modes de réalisation de la présente invention concernent également la préparation d'acétate de lasmiditan, d'un sel d'acétate de 2,4,6-trifluoro-N-[6-(1-méthylpipéridine-4-carbonyl)-2-pyridyl]benzamide, et/ou leurs compositions pharmaceutiques, et/ou des utilisations de l'acétate de lasmiditan et des formulations de ce dernier dans l'administration sous-cutanée de médicament.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESSES AND INTERMEDIATE FOR THE LARGE-SCALE PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE HEMISUCCINATE, AND PREPARATION OF 2,4,6-TRIFLUORO-N-[6-(1-METHYL-PIPERIDINE-4-CARBONYL)-PYRIDIN-2-YL]-BENZAMIDE ACETATE
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