QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS
Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant a...
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| creator | BARBOUR, PATRICK MICHAEL TARLTON, EUGENE BROWN, KATIE KEATON KAHN, DEAN RUSSELL PRIGARO, BRETT JOSEPH REN, LI HICKEN, ERIK JAMES MORENO, DAVID AUSTIN NEWHOUSE, BRADLEY JON METCALF, ANDREW TERRANCE PAJK, SPENCER PHILLIP LAIRD, ELLEN RUTH COOK, ADAM WADE |
| description | Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
L'invention concerne des composés de Formule I : et des sels, solvats et polymorphes pharmaceutiquement acceptables de ceux-ci, dans laquelle L, X1, R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, pour le traitement de maladies et de troubles associés à BRAF, notamment des tumeurs associées à BRAF, comprenant des tumeurs malignes et bénignes du SNC associées à BRAF et des tumeurs malignes extracraniennes associées à BRAF. |
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L'invention concerne des composés de Formule I : et des sels, solvats et polymorphes pharmaceutiquement acceptables de ceux-ci, dans laquelle L, X1, R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, pour le traitement de maladies et de troubles associés à BRAF, notamment des tumeurs associées à BRAF, comprenant des tumeurs malignes et bénignes du SNC associées à BRAF et des tumeurs malignes extracraniennes associées à BRAF.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230912&DB=EPODOC&CC=CA&NR=3144859C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230912&DB=EPODOC&CC=CA&NR=3144859C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARBOUR, PATRICK MICHAEL</creatorcontrib><creatorcontrib>TARLTON, EUGENE</creatorcontrib><creatorcontrib>BROWN, KATIE KEATON</creatorcontrib><creatorcontrib>KAHN, DEAN RUSSELL</creatorcontrib><creatorcontrib>PRIGARO, BRETT JOSEPH</creatorcontrib><creatorcontrib>REN, LI</creatorcontrib><creatorcontrib>HICKEN, ERIK JAMES</creatorcontrib><creatorcontrib>MORENO, DAVID AUSTIN</creatorcontrib><creatorcontrib>NEWHOUSE, BRADLEY JON</creatorcontrib><creatorcontrib>METCALF, ANDREW TERRANCE</creatorcontrib><creatorcontrib>PAJK, SPENCER PHILLIP</creatorcontrib><creatorcontrib>LAIRD, ELLEN RUTH</creatorcontrib><creatorcontrib>COOK, ADAM WADE</creatorcontrib><title>QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS</title><description>Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
L'invention concerne des composés de Formule I : et des sels, solvats et polymorphes pharmaceutiquement acceptables de ceux-ci, dans laquelle L, X1, R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, pour le traitement de maladies et de troubles associés à BRAF, notamment des tumeurs associées à BRAF, comprenant des tumeurs malignes et bénignes du SNC associées à BRAF et des tumeurs malignes extracraniennes associées à BRAF.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjLEKwjAURbs4iPoNvh_III2g4zN5oYGaYN5rB5dQJE6ihfr_WMTd6XLgnLus8qXzAa-x9UFpFQOBpeR7FN8TQ8fkuhZcTCANgSRCOVMQiA5OCZ1C5mg8Clmwngl5jjB8Iab5idfV4j48prL57araOhLTqDK-cpnG4Vae5Z0N1jutD_ujqf8bH425MlA</recordid><startdate>20230912</startdate><enddate>20230912</enddate><creator>BARBOUR, PATRICK MICHAEL</creator><creator>TARLTON, EUGENE</creator><creator>BROWN, KATIE KEATON</creator><creator>KAHN, DEAN RUSSELL</creator><creator>PRIGARO, BRETT JOSEPH</creator><creator>REN, LI</creator><creator>HICKEN, ERIK JAMES</creator><creator>MORENO, DAVID AUSTIN</creator><creator>NEWHOUSE, BRADLEY JON</creator><creator>METCALF, ANDREW TERRANCE</creator><creator>PAJK, SPENCER PHILLIP</creator><creator>LAIRD, ELLEN RUTH</creator><creator>COOK, ADAM WADE</creator><scope>EVB</scope></search><sort><creationdate>20230912</creationdate><title>QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS</title><author>BARBOUR, PATRICK MICHAEL ; TARLTON, EUGENE ; BROWN, KATIE KEATON ; KAHN, DEAN RUSSELL ; PRIGARO, BRETT JOSEPH ; REN, LI ; HICKEN, ERIK JAMES ; MORENO, DAVID AUSTIN ; NEWHOUSE, BRADLEY JON ; METCALF, ANDREW TERRANCE ; PAJK, SPENCER PHILLIP ; LAIRD, ELLEN RUTH ; COOK, ADAM WADE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3144859C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BARBOUR, PATRICK MICHAEL</creatorcontrib><creatorcontrib>TARLTON, EUGENE</creatorcontrib><creatorcontrib>BROWN, KATIE KEATON</creatorcontrib><creatorcontrib>KAHN, DEAN RUSSELL</creatorcontrib><creatorcontrib>PRIGARO, BRETT JOSEPH</creatorcontrib><creatorcontrib>REN, LI</creatorcontrib><creatorcontrib>HICKEN, ERIK JAMES</creatorcontrib><creatorcontrib>MORENO, DAVID AUSTIN</creatorcontrib><creatorcontrib>NEWHOUSE, BRADLEY JON</creatorcontrib><creatorcontrib>METCALF, ANDREW TERRANCE</creatorcontrib><creatorcontrib>PAJK, SPENCER PHILLIP</creatorcontrib><creatorcontrib>LAIRD, ELLEN RUTH</creatorcontrib><creatorcontrib>COOK, ADAM WADE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARBOUR, PATRICK MICHAEL</au><au>TARLTON, EUGENE</au><au>BROWN, KATIE KEATON</au><au>KAHN, DEAN RUSSELL</au><au>PRIGARO, BRETT JOSEPH</au><au>REN, LI</au><au>HICKEN, ERIK JAMES</au><au>MORENO, DAVID AUSTIN</au><au>NEWHOUSE, BRADLEY JON</au><au>METCALF, ANDREW TERRANCE</au><au>PAJK, SPENCER PHILLIP</au><au>LAIRD, ELLEN RUTH</au><au>COOK, ADAM WADE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS</title><date>2023-09-12</date><risdate>2023</risdate><abstract>Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.
L'invention concerne des composés de Formule I : et des sels, solvats et polymorphes pharmaceutiquement acceptables de ceux-ci, dans laquelle L, X1, R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, pour le traitement de maladies et de troubles associés à BRAF, notamment des tumeurs associées à BRAF, comprenant des tumeurs malignes et bénignes du SNC associées à BRAF et des tumeurs malignes extracraniennes associées à BRAF.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS |
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