5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES
Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart...
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| creator | OMOTO, KIYOYUKI REESE, MATTHEW RICHARD FILIPSKI, KEVIN JAMES ZHANG, YUAN KORMOS, BETHANY LYN MILLER, RUSSELL ALAN BHATTACHARYA, SAMIT KUMAR BUTLER, CHRISTOPHER RYAN MARTINEZ-ALSINA, LUIS ANGEL ROTH FLACH, RACHEL JANE RAYMER, BRIAN |
| description | Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.
L'invention concerne des composés de formule (I),R1, R2, et R3 étant tels que définis dans la description, leur utilisation en tant qu'inhibiteurs de kinase alpha-céto-déshydrogénase à chaîne ramifiée, des compositions pharmaceutiques contenant de tels inhibiteurs et l'utilisation de tels inhibiteurs pour traiter, par exemple, le diabète, la NASH et l'insuffisance cardiaque. |
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L'invention concerne des composés de formule (I),R1, R2, et R3 étant tels que définis dans la description, leur utilisation en tant qu'inhibiteurs de kinase alpha-céto-déshydrogénase à chaîne ramifiée, des compositions pharmaceutiques contenant de tels inhibiteurs et l'utilisation de tels inhibiteurs pour traiter, par exemple, le diabète, la NASH et l'insuffisance cardiaque.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231121&DB=EPODOC&CC=CA&NR=3144848C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231121&DB=EPODOC&CC=CA&NR=3144848C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OMOTO, KIYOYUKI</creatorcontrib><creatorcontrib>REESE, MATTHEW RICHARD</creatorcontrib><creatorcontrib>FILIPSKI, KEVIN JAMES</creatorcontrib><creatorcontrib>ZHANG, YUAN</creatorcontrib><creatorcontrib>KORMOS, BETHANY LYN</creatorcontrib><creatorcontrib>MILLER, RUSSELL ALAN</creatorcontrib><creatorcontrib>BHATTACHARYA, SAMIT KUMAR</creatorcontrib><creatorcontrib>BUTLER, CHRISTOPHER RYAN</creatorcontrib><creatorcontrib>MARTINEZ-ALSINA, LUIS ANGEL</creatorcontrib><creatorcontrib>ROTH FLACH, RACHEL JANE</creatorcontrib><creatorcontrib>RAYMER, BRIAN</creatorcontrib><title>5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES</title><description>Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.
L'invention concerne des composés de formule (I),R1, R2, et R3 étant tels que définis dans la description, leur utilisation en tant qu'inhibiteurs de kinase alpha-céto-déshydrogénase à chaîne ramifiée, des compositions pharmaceutiques contenant de tels inhibiteurs et l'utilisation de tels inhibiteurs pour traiter, par exemple, le diabète, la NASH et l'insuffisance cardiaque.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEOgjAQAFAWB6N-gzfq0AGBhLWUw14g1PQOEl0IIXUySoL_Hx3cnd7y1tGUqYNYcheLrTqpa3NUsVWC4vXNNQgleuq1UI8MmqEwdVkDtZYKEucZOsaqa6ByHsTjN7Zn6LUn1zGUxKgZeRut7uNjCbufm2hfoRirwvwawjKPU3iG92B0EqdpnuYm-T8-FaczJw</recordid><startdate>20231121</startdate><enddate>20231121</enddate><creator>OMOTO, KIYOYUKI</creator><creator>REESE, MATTHEW RICHARD</creator><creator>FILIPSKI, KEVIN JAMES</creator><creator>ZHANG, YUAN</creator><creator>KORMOS, BETHANY LYN</creator><creator>MILLER, RUSSELL ALAN</creator><creator>BHATTACHARYA, SAMIT KUMAR</creator><creator>BUTLER, CHRISTOPHER RYAN</creator><creator>MARTINEZ-ALSINA, LUIS ANGEL</creator><creator>ROTH FLACH, RACHEL JANE</creator><creator>RAYMER, BRIAN</creator><scope>EVB</scope></search><sort><creationdate>20231121</creationdate><title>5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES</title><author>OMOTO, KIYOYUKI ; REESE, MATTHEW RICHARD ; FILIPSKI, KEVIN JAMES ; ZHANG, YUAN ; KORMOS, BETHANY LYN ; MILLER, RUSSELL ALAN ; BHATTACHARYA, SAMIT KUMAR ; BUTLER, CHRISTOPHER RYAN ; MARTINEZ-ALSINA, LUIS ANGEL ; ROTH FLACH, RACHEL JANE ; RAYMER, BRIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3144848C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>OMOTO, KIYOYUKI</creatorcontrib><creatorcontrib>REESE, MATTHEW RICHARD</creatorcontrib><creatorcontrib>FILIPSKI, KEVIN JAMES</creatorcontrib><creatorcontrib>ZHANG, YUAN</creatorcontrib><creatorcontrib>KORMOS, BETHANY LYN</creatorcontrib><creatorcontrib>MILLER, RUSSELL ALAN</creatorcontrib><creatorcontrib>BHATTACHARYA, SAMIT KUMAR</creatorcontrib><creatorcontrib>BUTLER, CHRISTOPHER RYAN</creatorcontrib><creatorcontrib>MARTINEZ-ALSINA, LUIS ANGEL</creatorcontrib><creatorcontrib>ROTH FLACH, RACHEL JANE</creatorcontrib><creatorcontrib>RAYMER, BRIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OMOTO, KIYOYUKI</au><au>REESE, MATTHEW RICHARD</au><au>FILIPSKI, KEVIN JAMES</au><au>ZHANG, YUAN</au><au>KORMOS, BETHANY LYN</au><au>MILLER, RUSSELL ALAN</au><au>BHATTACHARYA, SAMIT KUMAR</au><au>BUTLER, CHRISTOPHER RYAN</au><au>MARTINEZ-ALSINA, LUIS ANGEL</au><au>ROTH FLACH, RACHEL JANE</au><au>RAYMER, BRIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES</title><date>2023-11-21</date><risdate>2023</risdate><abstract>Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.
L'invention concerne des composés de formule (I),R1, R2, et R3 étant tels que définis dans la description, leur utilisation en tant qu'inhibiteurs de kinase alpha-céto-déshydrogénase à chaîne ramifiée, des compositions pharmaceutiques contenant de tels inhibiteurs et l'utilisation de tels inhibiteurs pour traiter, par exemple, le diabète, la NASH et l'insuffisance cardiaque.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | 5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES |
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