TRICYCLIC AKR1C3 DEPENDENT KARS INHIBITORS

The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor. La présente inve...

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Bibliographische Detailangaben
Hauptverfasser:	NAKAJIMA, KATSUMASA, CHEN, TRACY, FRYER, CHRISTY, ADAIR, CHRIS, DING, JIAN, LARRAUFIE, MARIE-HELENE, SAVAGE, NIK, TWOMEY, ARIEL STERLING, ISOME, YUKO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor. La présente invention concerne des nouveaux composés tricycliques qui sont des inhibiteurs de KARS dépendant d'AKR1C3, des procédés pour leur préparation, des compositions pharmaceutiques, et des médicaments les contenant, ainsi que leur utilisation dans des maladies et des troubles médiés par l'inhibiteur de KARS dépendant d'AKR1C3.