2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF
The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said com...
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| creator | KAISER, MARTIN MAXMILIAN BIRKUS, GABRIEL PAV, ONDREJ BREHOVA, PETRA SIMAK, ONDREJ KOSTOV, ONDREJ |
| description | The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
La présente invention concerne des dinucléotides phosphonates cycliques en 2'3' de formule (I), leurs sels pharmaceutiquement acceptables, leur composition pharmaceutique et des associations desdites substances et d'autres médicaments ou produits pharmaceutiques. L'invention concerne également l'utilisation desdits composés pour le traitement ou la prévention de maladies ou d'états modifiables par la modulation de la protéine STING, tels que le cancer ou des maladies virales, allergiques et inflammatoires. En outre, ces substances peuvent être utilisées comme adjuvants dans des vaccins. |
| format | Patent |
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La présente invention concerne des dinucléotides phosphonates cycliques en 2'3' de formule (I), leurs sels pharmaceutiquement acceptables, leur composition pharmaceutique et des associations desdites substances et d'autres médicaments ou produits pharmaceutiques. L'invention concerne également l'utilisation desdits composés pour le traitement ou la prévention de maladies ou d'états modifiables par la modulation de la protéine STING, tels que le cancer ou des maladies virales, allergiques et inflammatoires. En outre, ces substances peuvent être utilisées comme adjuvants dans des vaccins.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CA&NR=3129022C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230801&DB=EPODOC&CC=CA&NR=3129022C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAISER, MARTIN MAXMILIAN</creatorcontrib><creatorcontrib>BIRKUS, GABRIEL</creatorcontrib><creatorcontrib>PAV, ONDREJ</creatorcontrib><creatorcontrib>BREHOVA, PETRA</creatorcontrib><creatorcontrib>SIMAK, ONDREJ</creatorcontrib><creatorcontrib>KOSTOV, ONDREJ</creatorcontrib><title>2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF</title><description>The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | 2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF |
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