CD44 TARGETED MULTI-ARM CONJUGATE
Disclosed is a class of multi-branched drug conjugates capable of specifically targeting CD44. The class of compounds specifically binds to CD44, and may target tumor cells and tissues having high expression of CD44, so that the concentration of the conjugate in a target tissue is high, the clinical...
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| creator | YUAN, JIANDONG SONG, YUNSONG HUANG, YANGQING |
| description | Disclosed is a class of multi-branched drug conjugates capable of specifically targeting CD44. The class of compounds specifically binds to CD44, and may target tumor cells and tissues having high expression of CD44, so that the concentration of the conjugate in a target tissue is high, the clinical treatment effect thereof is improved, and toxicity is reduced. The compound of the present invention is suitable for treating all tumors having high expression of CD44, comprising but not limited to gastric cancer, pancreatic cancer, small cell lung cancer, colon cancer, breast cancer, lung adenocarcinoma, liver cancer, nasopharyngeal carcinoma, malignant glioma, lymphoma, renal carcinoma, ovarian cancer, head and neck cancer, squamous cell carcinoma, and the like.
La présente invention concerne une classe de conjugués de médicament à branches multiples capable de cibler spécifiquement CD44. La classe de composés se lie spécifiquement à CD44, et peut cibler des cellules tumorales et des tissus ayant une expression élevée de CD44, de sorte que la concentration du conjugué dans un tissu cible est élevée, l'effet de traitement clinique de celui-ci est amélioré, et la toxicité est réduite. Le composé de la présente invention est adapté pour traiter toutes les tumeurs présentant une expression élevée de CD44, comprenant, sans limitation, un cancer gastrique, un cancer du pancréas, un cancer du poumon à petites cellules, un cancer du côlon, un cancer du sein, un adénocarcinome pulmonaire, un cancer du foie, un carcinome nasopharyngien, un gliome malin, un lymphome, un carcinome rénal, un cancer des ovaires, un cancer de la tête et du cou, un carcinome épidermoïde, et similaire. |
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La présente invention concerne une classe de conjugués de médicament à branches multiples capable de cibler spécifiquement CD44. La classe de composés se lie spécifiquement à CD44, et peut cibler des cellules tumorales et des tissus ayant une expression élevée de CD44, de sorte que la concentration du conjugué dans un tissu cible est élevée, l'effet de traitement clinique de celui-ci est amélioré, et la toxicité est réduite. Le composé de la présente invention est adapté pour traiter toutes les tumeurs présentant une expression élevée de CD44, comprenant, sans limitation, un cancer gastrique, un cancer du pancréas, un cancer du poumon à petites cellules, un cancer du côlon, un cancer du sein, un adénocarcinome pulmonaire, un cancer du foie, un carcinome nasopharyngien, un gliome malin, un lymphome, un carcinome rénal, un cancer des ovaires, un cancer de la tête et du cou, un carcinome épidermoïde, et similaire.</description><language>eng ; fre</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240625&DB=EPODOC&CC=CA&NR=3126574C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240625&DB=EPODOC&CC=CA&NR=3126574C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YUAN, JIANDONG</creatorcontrib><creatorcontrib>SONG, YUNSONG</creatorcontrib><creatorcontrib>HUANG, YANGQING</creatorcontrib><title>CD44 TARGETED MULTI-ARM CONJUGATE</title><description>Disclosed is a class of multi-branched drug conjugates capable of specifically targeting CD44. The class of compounds specifically binds to CD44, and may target tumor cells and tissues having high expression of CD44, so that the concentration of the conjugate in a target tissue is high, the clinical treatment effect thereof is improved, and toxicity is reduced. The compound of the present invention is suitable for treating all tumors having high expression of CD44, comprising but not limited to gastric cancer, pancreatic cancer, small cell lung cancer, colon cancer, breast cancer, lung adenocarcinoma, liver cancer, nasopharyngeal carcinoma, malignant glioma, lymphoma, renal carcinoma, ovarian cancer, head and neck cancer, squamous cell carcinoma, and the like.
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La présente invention concerne une classe de conjugués de médicament à branches multiples capable de cibler spécifiquement CD44. La classe de composés se lie spécifiquement à CD44, et peut cibler des cellules tumorales et des tissus ayant une expression élevée de CD44, de sorte que la concentration du conjugué dans un tissu cible est élevée, l'effet de traitement clinique de celui-ci est amélioré, et la toxicité est réduite. Le composé de la présente invention est adapté pour traiter toutes les tumeurs présentant une expression élevée de CD44, comprenant, sans limitation, un cancer gastrique, un cancer du pancréas, un cancer du poumon à petites cellules, un cancer du côlon, un cancer du sein, un adénocarcinome pulmonaire, un cancer du foie, un carcinome nasopharyngien, un gliome malin, un lymphome, un carcinome rénal, un cancer des ovaires, un cancer de la tête et du cou, un carcinome épidermoïde, et similaire.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | CD44 TARGETED MULTI-ARM CONJUGATE |
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