ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND
The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided...
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| creator | CHEN, XIAOHUA WANG, YUJIE LI, JIA NIE, HUIJUN KAN, WEIJUAN ZHOU, YUBO CHENG, YU GUO, ANDI |
| description | The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBNE3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBNE3 ubiquitin ligase. (I)
La présente invention concerne un composé d'isoindoline tel que représenté par la formule générale (I), utilisé en tant que régulateur CRBN, et un procédé de préparation, une composition pharmaceutique ainsi qu'une utilisation du composé d'isoindoline. Plus particulièrement, l'invention concerne une classe de composé d'isoindoline polysubstitué utilisée en tant que classe de régulateur de l'ubiquitine ligase CRL4CRBNE3 ayant une nouvelle structure, ladite classe de composé présente une bonne activité antitumorale et une bonne activité immunorégulatrice, et peut être utilisée pour préparer des médicaments pour le traitement de maladies associées à l'ubiquitine ligase CRL4CRBNE3. (I) |
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La présente invention concerne un composé d'isoindoline tel que représenté par la formule générale (I), utilisé en tant que régulateur CRBN, et un procédé de préparation, une composition pharmaceutique ainsi qu'une utilisation du composé d'isoindoline. Plus particulièrement, l'invention concerne une classe de composé d'isoindoline polysubstitué utilisée en tant que classe de régulateur de l'ubiquitine ligase CRL4CRBNE3 ayant une nouvelle structure, ladite classe de composé présente une bonne activité antitumorale et une bonne activité immunorégulatrice, et peut être utilisée pour préparer des médicaments pour le traitement de maladies associées à l'ubiquitine ligase CRL4CRBNE3. (I)</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200611&DB=EPODOC&CC=CA&NR=3122317A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200611&DB=EPODOC&CC=CA&NR=3122317A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN, XIAOHUA</creatorcontrib><creatorcontrib>WANG, YUJIE</creatorcontrib><creatorcontrib>LI, JIA</creatorcontrib><creatorcontrib>NIE, HUIJUN</creatorcontrib><creatorcontrib>KAN, WEIJUAN</creatorcontrib><creatorcontrib>ZHOU, YUBO</creatorcontrib><creatorcontrib>CHENG, YU</creatorcontrib><creatorcontrib>GUO, ANDI</creatorcontrib><title>ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND</title><description>The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBNE3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBNE3 ubiquitin ligase. (I)
La présente invention concerne un composé d'isoindoline tel que représenté par la formule générale (I), utilisé en tant que régulateur CRBN, et un procédé de préparation, une composition pharmaceutique ainsi qu'une utilisation du composé d'isoindoline. Plus particulièrement, l'invention concerne une classe de composé d'isoindoline polysubstitué utilisée en tant que classe de régulateur de l'ubiquitine ligase CRL4CRBNE3 ayant une nouvelle structure, ladite classe de composé présente une bonne activité antitumorale et une bonne activité immunorégulatrice, et peut être utilisée pour préparer des médicaments pour le traitement de maladies associées à l'ubiquitine ligase CRL4CRBNE3. (I)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZCj0DPb39HPx9_H0c1Vw9vcN8A_1c9FRcPRzUQgIcg1wDHIM8fT3U_B1DfHwB4oHeDgG-To6u4aGeDo7-kA0BHuClED0OAYE-ABlwHr83RSwGc7DwJqWmFOcyguluRkU3FxDnD10Uwvy41OLCxKTU_NSS-KdHY0NjYyMDc0dDY2JUAIAufc3uA</recordid><startdate>20200611</startdate><enddate>20200611</enddate><creator>CHEN, XIAOHUA</creator><creator>WANG, YUJIE</creator><creator>LI, JIA</creator><creator>NIE, HUIJUN</creator><creator>KAN, WEIJUAN</creator><creator>ZHOU, YUBO</creator><creator>CHENG, YU</creator><creator>GUO, ANDI</creator><scope>EVB</scope></search><sort><creationdate>20200611</creationdate><title>ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND</title><author>CHEN, XIAOHUA ; WANG, YUJIE ; LI, JIA ; NIE, HUIJUN ; KAN, WEIJUAN ; ZHOU, YUBO ; CHENG, YU ; GUO, ANDI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3122317A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN, XIAOHUA</creatorcontrib><creatorcontrib>WANG, YUJIE</creatorcontrib><creatorcontrib>LI, JIA</creatorcontrib><creatorcontrib>NIE, HUIJUN</creatorcontrib><creatorcontrib>KAN, WEIJUAN</creatorcontrib><creatorcontrib>ZHOU, YUBO</creatorcontrib><creatorcontrib>CHENG, YU</creatorcontrib><creatorcontrib>GUO, ANDI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN, XIAOHUA</au><au>WANG, YUJIE</au><au>LI, JIA</au><au>NIE, HUIJUN</au><au>KAN, WEIJUAN</au><au>ZHOU, YUBO</au><au>CHENG, YU</au><au>GUO, ANDI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND</title><date>2020-06-11</date><risdate>2020</risdate><abstract>The present invention relates to an isoindoline compound as represented by general formula (I) and used as a CRBN regulator, and a preparation method, a pharmaceutical composition, and an application of the isoindoline compound. Specifically, a class of polysubstituted isoindoline compound provided in the present invention, as a class of CRL4CRBNE3 ubiquitin ligase regulator having a novel structure, has good anti-tumor activity and immunoregulatory activity, and can be used for preparing drugs for treating diseases associated with a CRL4CRBNE3 ubiquitin ligase. (I)
La présente invention concerne un composé d'isoindoline tel que représenté par la formule générale (I), utilisé en tant que régulateur CRBN, et un procédé de préparation, une composition pharmaceutique ainsi qu'une utilisation du composé d'isoindoline. Plus particulièrement, l'invention concerne une classe de composé d'isoindoline polysubstitué utilisée en tant que classe de régulateur de l'ubiquitine ligase CRL4CRBNE3 ayant une nouvelle structure, ladite classe de composé présente une bonne activité antitumorale et une bonne activité immunorégulatrice, et peut être utilisée pour préparer des médicaments pour le traitement de maladies associées à l'ubiquitine ligase CRL4CRBNE3. (I)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND |
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