METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS
Methods for determining the likelihood that a subject suffering from a solid tumor cancer will benefit from treatment with an illudin are disclosed herein. Further, there are also methods for treatment based on such determination. In several embodiments, markers prostaglandin reductase 1 (PTGR1), Pr...
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| creator | VEDARAJU, YUVANESH KULKAMI, ADITYA KATHAD, UMESH ASAITHAMBI, ARUN |
| description | Methods for determining the likelihood that a subject suffering from a solid tumor cancer will benefit from treatment with an illudin are disclosed herein. Further, there are also methods for treatment based on such determination. In several embodiments, markers prostaglandin reductase 1 (PTGR1), Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), Aspartate Beta- Hydroxylase (ASPH) together with one or more genes or alone may be used to enhance or guide treatment with an illudin. In certain embodiments, the protein or gene may be expressed or methylated.
La présente invention concerne des procédés de détermination de la probabilité qu'un sujet souffrant d'un cancer à tumeur solide pourrait bénéficier du traitement avec une illudine. En outre, l'invention concerne également des procédés de traitement en fonction d'une telle détermination. Dans plusieurs modes de réalisation, les marqueurs prostaglandine réductase (1) (PTGR1), protéine tyrosine phosphatase type non-récepteur 14 (PTPN14), l'aspartate bêta-hydroxylase (ASPH) conjointement à un ou plusieurs gènes ou seul peuvent être utilisés pour améliorer ou guider le traitement avec une illudine. Dans certains modes de réalisation, la protéine ou le gène peut être exprimé ou méthylé. |
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La présente invention concerne des procédés de détermination de la probabilité qu'un sujet souffrant d'un cancer à tumeur solide pourrait bénéficier du traitement avec une illudine. En outre, l'invention concerne également des procédés de traitement en fonction d'une telle détermination. Dans plusieurs modes de réalisation, les marqueurs prostaglandine réductase (1) (PTGR1), protéine tyrosine phosphatase type non-récepteur 14 (PTPN14), l'aspartate bêta-hydroxylase (ASPH) conjointement à un ou plusieurs gènes ou seul peuvent être utilisés pour améliorer ou guider le traitement avec une illudine. Dans certains modes de réalisation, la protéine ou le gène peut être exprimé ou méthylé.</description><language>eng ; fre</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200423&DB=EPODOC&CC=CA&NR=3116552A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200423&DB=EPODOC&CC=CA&NR=3116552A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VEDARAJU, YUVANESH</creatorcontrib><creatorcontrib>KULKAMI, ADITYA</creatorcontrib><creatorcontrib>KATHAD, UMESH</creatorcontrib><creatorcontrib>ASAITHAMBI, ARUN</creatorcontrib><title>METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS</title><description>Methods for determining the likelihood that a subject suffering from a solid tumor cancer will benefit from treatment with an illudin are disclosed herein. Further, there are also methods for treatment based on such determination. In several embodiments, markers prostaglandin reductase 1 (PTGR1), Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), Aspartate Beta- Hydroxylase (ASPH) together with one or more genes or alone may be used to enhance or guide treatment with an illudin. In certain embodiments, the protein or gene may be expressed or methylated.
La présente invention concerne des procédés de détermination de la probabilité qu'un sujet souffrant d'un cancer à tumeur solide pourrait bénéficier du traitement avec une illudine. En outre, l'invention concerne également des procédés de traitement en fonction d'une telle détermination. Dans plusieurs modes de réalisation, les marqueurs prostaglandine réductase (1) (PTGR1), protéine tyrosine phosphatase type non-récepteur 14 (PTPN14), l'aspartate bêta-hydroxylase (ASPH) conjointement à un ou plusieurs gènes ou seul peuvent être utilisés pour améliorer ou guider le traitement avec une illudine. Dans certains modes de réalisation, la protéine ou le gène peut être exprimé ou méthylé.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEOwiAQgGEWB6O-w72AQ23qfsIhRDgSOOamMTgZbVLfP3bwAZz-4fu3iiOJS6aATRnEEUgmlEgskCyUFLwBqXFFjawpF6jF8xV8CNV4LoBs4OJTxHxbda82j-m5tMOvOwWWRLtjm99jW-bp3l7tM2rsu-48DCfs-j-WL7NtLes</recordid><startdate>20200423</startdate><enddate>20200423</enddate><creator>VEDARAJU, YUVANESH</creator><creator>KULKAMI, ADITYA</creator><creator>KATHAD, UMESH</creator><creator>ASAITHAMBI, ARUN</creator><scope>EVB</scope></search><sort><creationdate>20200423</creationdate><title>METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS</title><author>VEDARAJU, YUVANESH ; KULKAMI, ADITYA ; KATHAD, UMESH ; ASAITHAMBI, ARUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3116552A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VEDARAJU, YUVANESH</creatorcontrib><creatorcontrib>KULKAMI, ADITYA</creatorcontrib><creatorcontrib>KATHAD, UMESH</creatorcontrib><creatorcontrib>ASAITHAMBI, ARUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VEDARAJU, YUVANESH</au><au>KULKAMI, ADITYA</au><au>KATHAD, UMESH</au><au>ASAITHAMBI, ARUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS</title><date>2020-04-23</date><risdate>2020</risdate><abstract>Methods for determining the likelihood that a subject suffering from a solid tumor cancer will benefit from treatment with an illudin are disclosed herein. Further, there are also methods for treatment based on such determination. In several embodiments, markers prostaglandin reductase 1 (PTGR1), Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), Aspartate Beta- Hydroxylase (ASPH) together with one or more genes or alone may be used to enhance or guide treatment with an illudin. In certain embodiments, the protein or gene may be expressed or methylated.
La présente invention concerne des procédés de détermination de la probabilité qu'un sujet souffrant d'un cancer à tumeur solide pourrait bénéficier du traitement avec une illudine. En outre, l'invention concerne également des procédés de traitement en fonction d'une telle détermination. Dans plusieurs modes de réalisation, les marqueurs prostaglandine réductase (1) (PTGR1), protéine tyrosine phosphatase type non-récepteur 14 (PTPN14), l'aspartate bêta-hydroxylase (ASPH) conjointement à un ou plusieurs gènes ou seul peuvent être utilisés pour améliorer ou guider le traitement avec une illudine. Dans certains modes de réalisation, la protéine ou le gène peut être exprimé ou méthylé.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | METHODS FOR THE TREATMENT OF SOLID TUMOR CANCERS USING ILLUDINS AND BIOMARKERS |
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