COMBINATORIAL CANCER IMMUNOTHERAPY
Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well a...
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| creator | FRIMANNSSON, DANIEL LEE, PHILIP JANMIN GORDLEY, RUSSELL MORRISON GARRISON, BRIAN SCOTT GONZALEZ-JUNCA, ALBA WANG, DON-HONG LU, TIMOTHY KUAN-TA LIN, JACK TZUIAO |
| description | Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
La présente invention concerne des méthodes et des compositions permettant de contrôler et de cibler de manière dynamique de multiples mécanismes immunosuppresseurs dans le cancer. Certains aspects concernent des cellules modifiées pour produire de multiples molécules effectrices, chacune d'entre elles modulant un mécanisme immunosuppresseur différent d'une tumeur, ainsi que des procédés d'utilisation des cellules pour traiter le cancer, tel que le cancer de l'ovaire, du sein ou du côlon. |
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La présente invention concerne des méthodes et des compositions permettant de contrôler et de cibler de manière dynamique de multiples mécanismes immunosuppresseurs dans le cancer. Certains aspects concernent des cellules modifiées pour produire de multiples molécules effectrices, chacune d'entre elles modulant un mécanisme immunosuppresseur différent d'une tumeur, ainsi que des procédés d'utilisation des cellules pour traiter le cancer, tel que le cancer de l'ovaire, du sein ou du côlon.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200423&DB=EPODOC&CC=CA&NR=3116138A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200423&DB=EPODOC&CC=CA&NR=3116138A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FRIMANNSSON, DANIEL</creatorcontrib><creatorcontrib>LEE, PHILIP JANMIN</creatorcontrib><creatorcontrib>GORDLEY, RUSSELL MORRISON</creatorcontrib><creatorcontrib>GARRISON, BRIAN SCOTT</creatorcontrib><creatorcontrib>GONZALEZ-JUNCA, ALBA</creatorcontrib><creatorcontrib>WANG, DON-HONG</creatorcontrib><creatorcontrib>LU, TIMOTHY KUAN-TA</creatorcontrib><creatorcontrib>LIN, JACK TZUIAO</creatorcontrib><title>COMBINATORIAL CANCER IMMUNOTHERAPY</title><description>Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
La présente invention concerne des méthodes et des compositions permettant de contrôler et de cibler de manière dynamique de multiples mécanismes immunosuppresseurs dans le cancer. Certains aspects concernent des cellules modifiées pour produire de multiples molécules effectrices, chacune d'entre elles modulant un mécanisme immunosuppresseur différent d'une tumeur, ainsi que des procédés d'utilisation des cellules pour traiter le cancer, tel que le cancer de l'ovaire, du sein ou du côlon.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBy9vd18vRzDPEP8nT0UXB29HN2DVLw9PUN9fMP8XANcgyI5GFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8c6OxoaGZobGFo6GxkQoAQAIlSIf</recordid><startdate>20200423</startdate><enddate>20200423</enddate><creator>FRIMANNSSON, DANIEL</creator><creator>LEE, PHILIP JANMIN</creator><creator>GORDLEY, RUSSELL MORRISON</creator><creator>GARRISON, BRIAN SCOTT</creator><creator>GONZALEZ-JUNCA, ALBA</creator><creator>WANG, DON-HONG</creator><creator>LU, TIMOTHY KUAN-TA</creator><creator>LIN, JACK TZUIAO</creator><scope>EVB</scope></search><sort><creationdate>20200423</creationdate><title>COMBINATORIAL CANCER IMMUNOTHERAPY</title><author>FRIMANNSSON, DANIEL ; LEE, PHILIP JANMIN ; GORDLEY, RUSSELL MORRISON ; GARRISON, BRIAN SCOTT ; GONZALEZ-JUNCA, ALBA ; WANG, DON-HONG ; LU, TIMOTHY KUAN-TA ; LIN, JACK TZUIAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3116138A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FRIMANNSSON, DANIEL</creatorcontrib><creatorcontrib>LEE, PHILIP JANMIN</creatorcontrib><creatorcontrib>GORDLEY, RUSSELL MORRISON</creatorcontrib><creatorcontrib>GARRISON, BRIAN SCOTT</creatorcontrib><creatorcontrib>GONZALEZ-JUNCA, ALBA</creatorcontrib><creatorcontrib>WANG, DON-HONG</creatorcontrib><creatorcontrib>LU, TIMOTHY KUAN-TA</creatorcontrib><creatorcontrib>LIN, JACK TZUIAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FRIMANNSSON, DANIEL</au><au>LEE, PHILIP JANMIN</au><au>GORDLEY, RUSSELL MORRISON</au><au>GARRISON, BRIAN SCOTT</au><au>GONZALEZ-JUNCA, ALBA</au><au>WANG, DON-HONG</au><au>LU, TIMOTHY KUAN-TA</au><au>LIN, JACK TZUIAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMBINATORIAL CANCER IMMUNOTHERAPY</title><date>2020-04-23</date><risdate>2020</risdate><abstract>Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
La présente invention concerne des méthodes et des compositions permettant de contrôler et de cibler de manière dynamique de multiples mécanismes immunosuppresseurs dans le cancer. Certains aspects concernent des cellules modifiées pour produire de multiples molécules effectrices, chacune d'entre elles modulant un mécanisme immunosuppresseur différent d'une tumeur, ainsi que des procédés d'utilisation des cellules pour traiter le cancer, tel que le cancer de l'ovaire, du sein ou du côlon.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | COMBINATORIAL CANCER IMMUNOTHERAPY |
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