SOLID DISPERSION COMPRISING AN ANTICANCER COMPOUND FOR IMPROVED SOLUBILITY AND EFFICACY

The present invention is related to the novel solid dispersion formulations of an anticancer compound of formula A and a process for preparing the same wherein the anticancer compound is formulated with hydrophilic polymer. The said formulation showed enhanced dissolution of the anticancer compound...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BHARATE, SANDIP BIBISHAN, MINTOO, MUBASHIR JAVED, KUMAR, VIKAS, MONDHE, DILIP MANIKRAO, VISHWAKARMA, RAM, BHARATE, SONALI SANDIP
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is related to the novel solid dispersion formulations of an anticancer compound of formula A and a process for preparing the same wherein the anticancer compound is formulated with hydrophilic polymer. The said formulation showed enhanced dissolution of the anticancer compound and improved in-vivo anticancer activity. The said formulations are useful for the treatment of various types of cancer. La présente invention concerne les nouvelles formulations de dispersion solide d'un composé anticancéreux de formule A et un procédé de préparation de celles-ci, le composé anticancéreux étant formulé avec un polymère hydrophile. Ladite formulation a présenté une dissolution améliorée du composé anticancéreux et une activité anticancéreuse in vivo améliorée. Lesdites formulations sont utiles pour le traitement de divers types de cancer.