PENAM DERIVATIVE OR SALT THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF

The problem addressed by the present invention is to provide compounds and pharmaceutical compositions that demonstrate strong antibacterial activity against gram-negative bacteria and drug-resistant gram-negative bacteria. Compounds represented by general formula [1] (in the formula, each symbol is...

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Hauptverfasser: FURUYA, KENTARO, SHOJI, MUNEO, MATSUURA, KEI, NAKAE, TOMOFUMI
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creator FURUYA, KENTARO
SHOJI, MUNEO
MATSUURA, KEI
NAKAE, TOMOFUMI
description The problem addressed by the present invention is to provide compounds and pharmaceutical compositions that demonstrate strong antibacterial activity against gram-negative bacteria and drug-resistant gram-negative bacteria. Compounds represented by general formula [1] (in the formula, each symbol is as described in the specification.) or salts thereof have strong antibacterial activity against gram-negative bacteria, including Pseudomonas aeruginosa, and drug-resistant gram-negative bacteria, including multidrug-resistant Pseudomonas aeruginosa, and pharmaceutical compositions containing these compounds or salts are useful as antimicrobials. Le problème à résoudre par la présente invention concerne la fourniture de composés et de compositions pharmaceutiques présentant une forte activité antibactérienne contre des bactéries à Gram-négatif et des bactéries à Gram-négatif résistantes aux médicaments. L'invention concerne des composés représentés par la formule [1] (dans laquelle, chaque symbole est tel que défini dans la description), ou des sels de ceux-ci ayant une forte activité antibactérienne contre des bactéries à Gram négatif, y compris Pseudomonas aeruginosa, et des bactéries à Gram-négatif résistantes aux médicaments, y compris Pseudomonas aeruginosa résistante aux médicaments, ainsi que des compositions pharmaceutiques contenant ces composés ou ces sels utiles en tant qu'agents antimicrobiens.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PENAM DERIVATIVE OR SALT THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF
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